Principal AI Architect

McKesson is an impact-driven Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights products and services that make quality care more accessible and affordable. Here we focus on the health happiness and well-being of you and those we serve we care.

What you do at McKesson matters. We foster a culture where you can grow make an impact and are empowered to bring new ideas. Together we thrive as we shape the future of health for patients our communities and our people. If you want to be part of tomorrows health today we want to hear from you.

Position Summary:

The Principal AI Architect Responsible AI is the enterprises chief technical authority on responsible AI design and governance-by-architecture. This individual defines the standards reference architectures and technical guardrails that ensure every AI/ML system from classical ML to agentic AI meets regulatory ethical and quality thresholds before reaching production. The role bridges deep technical fluency with enterprise strategy translating board-level risk appetite into enforceable architectural patterns across the full AI lifecycle.

Key Responsibilities:

• Define and maintain enterprise Responsible AI standards policies and technical guidelines covering fairness explainability robustness privacy and safety across all AI/ML modalities (predictive generative agentic).

• Establish model risk tiering frameworks aligned with regulatory requirements (e.g. EU AI Act risk categories NIST AI RMF FDA/SaMD where applicable) and map technical controls to each tier.

• Lead Enterprise Architecture Review Board (EARB) reviews for AI/ML solutions ensuring compliance with responsible AI standards before production deployment.

• Partner with Legal Compliance Privacy and InfoSec to translate regulatory and contractual obligations into testable technical requirements.

• Develop and evangelize an enterprise AI ethics review process including impact assessments red-teaming protocols and human-in-the-loop escalation criteria for high-risk use cases.

• Mentor and coach ML Engineers Data Scientists and Platform Engineers on responsible AI patterns and anti-patterns; create reusable design patterns templates and decision frameworks.

• Represent the enterprises responsible AI posture to external auditors regulators customers and industry working groups.

• Track the evolving responsible AI landscape (tooling regulation academic research) and recommend adoption of emerging capabilities.

Minimum Qualifications:

• Degree or equivalent andtypically requires 13 yearswith 8 years of direct work related experience. Less yearsrequired if has relevant Mastersor Doctorate qualifications.

Critical Experience/Skills:

• Extensive experience in AI/ML engineering architecture or applied research with at least 3 years focused on AI governance fairness or safety.

• Deep expertise in at least two: bias/fairness measurement explainability methods (SHAP LIME counterfactual) adversarial robustness differential privacy or AI safety alignment.

• Demonstrated experience authoring enterprise-level AI standards policies or reference architectures adopted across multiple business units.

• Strong working knowledge of regulatory frameworks: NIST AI RMF EU AI Act ISO 42001 SOC 2 AI considerations and sector-specific requirements (healthcare financial services).

• Experience presenting technical governance topics to executive leadership and board-level audiences.

Preferred Experience/Skills:

• Experience with agentic AI architectures and the unique governance challenges they present (tool-use authorization multi-agent orchestration autonomous decision boundaries).

• Contributions to responsible AI open-source projects publications or industry standards bodies.

• Healthcare or pharmaceutical industry experience.

• Masters degree (in Computer Science AI/ML Statistics or related quantitative field) or PhD preferred.

We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors including performance experience and skills equity regular job market evaluations and geographical markets. The pay range shown below is aligned with McKessons pay philosophy and pay will always be compliant with any applicable regulations. In addition to base pay other compensation such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson pleaseclick here.

Our Base Pay Range for this position

McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKessons (or affiliated entities like CoverMyMeds or RxCrossroads) name in fraudulent emails job postings or social media light of these scams please bear the following in mind:

McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.

McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.

McKesson job postings are posted on our career site: .

McKesson is an Equal Opportunity Employer

McKesson provides equal employment opportunities to applicants and employees without regard to race color religion sex sexual orientation gender identity national origin protected veteran status disability age genetic information or any other legally protected category. For additional information on McKessons full Equal Employment Opportunity policies visit our Equal Employment Opportunity page.

McKesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment please contact us by sending an email to (United States) or (Canada) . Resumes or CVs submitted to this email box will not be accepted.

Join us at McKesson!