Research Scientist, Protein Sciences

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Job Description

We are seeking a highly motivated Research Scientist to join our Protein Sciences team. This individual will lead from the bench while owning endtoend responsibility for the design expression purification and characterization of recombinant proteins supporting multiple CART and cell therapy programs.

The successful candidate will function as an individual scientific contributor and operational leader partnering closely with Cell Biology Protein Science and crossfunctional teams while also serving as a daytoday lab and capability owner across protein production and analytics workflows.

Key Responsibilities

Molecule Design & Scientific Contribution

• Design and engineer fitforpurpose recombinant proteins including immunogens target proteins antibodies and protein variants to support discovery and development programs

• Contribute to molecule design decisions construct strategy and experimental planning in partnership with project teams

• Apply protein engineering principles to optimize expression stability and performance

Protein Production & Analytics

• This role is primarily wet-lab-based and requires regular on-site laboratory presence

• Execute and optimize protein expression and purification across multiple expression systems (including cell maintenance and transfections). Experience with AKTA chromatography platforms is required.

• Perform antibody and protein conjugations with appropriate analytical characterization

• Lead biophysical and biochemical characterization including SDSPAGE Western blot UPLC/HPLC analysis and binding assays (e.g. Octet/BLI)

• Interpret and communicate analytical data to inform project decisions and nextstep prioritization

Technology Development & Continuous Improvement

• Develop optimize and implement new protein production and analytical workflows to improve quality throughput and reproducibility

• Identify gaps in capabilities and proactively propose solutions or process improvements

Operational & Lab Leadership

• Function as a lab lead including oversight of shared equipment reagent organization documentation standards and daytoday lab operations

• Demonstrated commitment to highquality documentation and data integrity with proven experience using electronic lab notebooks and LIMS platforms (e.g. Benchling) to support reproducibility traceability and crossteam collaboration. Design workflow templates and contribute to improvement of workflow digitization.

• Coordinate work across multiple projects balancing priorities and timelines with minimal supervision

Team & Communication

• Train mentor and technically support junior scientists and staff

• Communicate plans data and conclusions clearly in both written reports and oral presentations

• Provide strong scientific and operational partnership through effective cross-functional communication and collaboration

Basic Qualifications

• Advanced scientific degree (MD PharmD PhD)
  OR

• Masters degree with 4 years of relevant scientific experience
  OR

• Bachelors degree with 6 years of relevant scientific experience

Preferred Qualifications

• PhD in Biochemistry Chemistry Biology or related field

• Industry and/or postdoctoral experience with demonstrated scientific independence supported by peer-reviewed publications and presentations

• Demonstrated ability to operate in a fast-paced rapidly changing environment with strong time management and adaptability

• Deep expertise in recombinant protein expression purification and analytics

• Demonstrated ability to own complex workflows endtoend from design through data interpretation

• Proven troubleshooting and problemsolving skills in a fastpaced multiprogram environment

• Demonstrated expertise in biomolecular binding affinity and kinetics measurements using Biolayer Interferometry (BLI e.g. Octet) and/or Surface Plasmon Resonance (SPR)

• Experience acting as an informal lab lead or operational owner

• Strong organizational skills attention to detail and commitment to highquality data generation

• Excellent interpersonal written and verbal communication skills

• Ability to work onsite in a laboratory environment

For additional benefits information visit:

Eligible employees may participate in benefit plans subject to the terms and conditions of the applicable plans.

Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune systems ability to recognize and kill tumors. Kite is based in Santa Monica CA. For more information on Kite please visit . Sign up to follow @KitePharma on Twitter at jobs in the United States:

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