Director, Rinzimetostat CMC Development Team Leader

1. End-to-End CMC Leadership & Cross-Functional Integration

• Create and execute against integrated cross-functional project plans leading the integrated CMC strategy.
• Translate program strategy into cohesive development manufacturing and supply plans with clear milestones and deliverables.
• Drive cross-functional alignment in close partnership with Clinical Development Regulatory Affairs Quality Supply Chain Commercial and Finance teams.
• Guide and lead project performance risk and financial management and issues resolution for functional groups.
• Provide direction on requirements to meet internal and external stakeholders expectations.
• Ensure CMC activities are executed in lockstep with clinical timelines regulatory milestones and commercial launch plans.
• Serve as the CMC representative on program governance teams influencing key decisions and trade-offs across functions.

2. Budget Planning & Financial Stewardship

• Develop and manage comprehensive CMC budgets including development manufacturing and supply chain costs.
• Drive financial planning forecasting and scenario modeling to support program and portfolio decisions.
• Identify and implement cost optimization strategies without compromising quality timelines or regulatory compliance.
• Partner with Finance to ensure transparency accountability and disciplined capital allocation.
• Evaluate investment trade-offs and provide data-driven recommendations to senior leadership.

3. Strategic CMO/CDMO Oversight & External Partnerships

• Define and execute a robust external manufacturing strategy including selection onboarding and management of CMOs/CDMOs.
• Establish performance expectations KPIs and governance frameworks for external partners.
• Lead regular business reviews ensuring accountability for delivery quality cost and timelines.
• Proactively identify and mitigate risks across the external network including capacity quality and supply continuity risks.
• Drive strong collaborative partnerships while maintaining rigorous oversight and escalation processes when needed.

4. Program Leadership & Governance

• Operate as a GM for the program for CMC accountable for delivery against timeline cost and quality objectives.
• Provide clear concise communication and executive-level updates on risks progress and mitigation strategies.
• Build alignment across stakeholders and drive decisive forward-looking decision-making.

Qualifications :

Education & Experience

• Advanced degree (PhD MS or equivalent) in Chemical Engineering Pharmaceutical Sciences Chemistry or related field.
• 12 years of experience in biopharma CMC development with increasing leadership responsibility.
• Demonstrated success leading programs through commercialization including NDA filing and launch.

Core Capabilities

• Deep expertise in CMC development manufacturing and regulatory requirements.
• Proven ability to lead highly cross-functional matrixed teams.
• Strong track record of budget ownership and financial decision-making.
• Extensive experience managing CMOs/CDMOs at a strategic level including performance governance.
• Ability to balance technical rigor with business and commercial considerations.
• Exceptional communication influence and leadership skills.

Leadership Profile

• Strategic thinker with strong execution discipline
• Comfortable navigating ambiguity and complexity
• Data-driven with strong business and financial acumen
• Collaborative but decisive and accountable
• High ownership mindset with a focus on outcomes

Additional Information :

The anticipated salary range for director level candidates who will work on-site at our South San Francisco location is between $230000-$270000. The final wage offered to a successful candidate will be dependent on several factors that may include title type and length of experience within the role type and length of experience within the industry education geography and other job-related factors.

ORIC Pharmaceuticals Inc. is an equal opportunity employer. ORIC does not discriminate based on race color religion gender sexual orientation gender identity age national origin disability status protected veteran status or any other legally protected characteristics.

Remote Work :

No

Employment Type :

Full-time