Manager Bioreactor Process Development

Permanent position

Based in Toulouse France

Were excited to share this opportunity is part of the Sandoz acquisition of Just-Evotec Biologics in Toulouse. Through this opportunity you will impact the lives of hundreds of millions of people through bold ideas supported by an inclusive agile company culture. Join us to help make healthcare fairer and faster help us to pioneer access to medicine! Click to learn more.

Missions and responsibilities :

• Lead a diverse group of scientists responsible for development and tech transfer of early and late-stage (characterization and validation) upstream perfusion/intensified fed-batch processes for biotherapeutics manufacturing as well as technology development projects.

• Prepare and run bench-scale bioreactors and bioreactor-related equipment (controllers pumps autoclaves etc.). This may include but not limited to build and autoclave bioreactor parts and assemblies as well as assisting with bench-scale bioreactor operations (daily sampling and analytics inoculation activities run preparation and troubleshooting).

• Serve as a functional area lead for platform or complex client early-stage (FIH) and late-stage Process Characterization (PC) projects as well as technology development projects.

• Serve as an internal technical resource for cGMP manufacturing and Process Design as well as a resource and subject matter expert for external clients and partners for cell culture and bioreactor processes (small scale models process transfer and scale up).

• Communicate experimental plans and data to teams and clients clearly and effectively including communicating scientific information to a diverse set of audiences including external clients vendors and technology development collaborators.

• Independently design execute and analyze statistically designed experiments (DOE).

• Author SOPs reports and slides which summarize organize and interpret experiment results with review by appropriate team members.

• Train mentor and supervise junior staff and interns.

• Potential for weekend work and being on-call for critical bioreactor runs.

Knowledge skills and abilities :

• Expertise in bioreactor cell culture and perfusion technology development and tech as well ass CMC sections authoring for regulatory filings.

• Experience in Biosimilar development

• Experience with commercial process development process characterization and validation.

• Expertise in design of experiments (DOE) and statistical analysis.

• Experience with high throughput cell culture (e.g. HT assays robotics such as Ambr systems lab automation or multi-omic data) is a plus.

Pluses

• Experience analyzing data in tools such as JMP R or Python.

• General understanding of cell biology fluid dynamics and biotransport as well as knowledge in other functional areas (downstream purification and analytical sciences).

• General understanding of circuits (grounding power signal etc.).

• Experience working in a cGMP or clean room setting (this job is non-GMP but knowledge of GMP is helpful for process/tech transfer activities).

Experience and education :

• Masters in engineering Biochemistry Biology or related field with 8 years of experience or Ph.D. in Engineering Biochemistry Biology or related field with 6 years of experience.

• Proficiency in both verbal and written English is essential.

Other information :

Availability to work on weekends and evenings is required.

Why Sandoz

Generic and Biosimilar medicines are the backbone of the global medicines industry. Sandoz a leader in this sector touched the lives of almost 500 million patients last year and while we are proud of this achievement we have an ambition to do more!

With investments in new development capabilities state-of-the-art production sites new acquisitions and partnerships we have the opportunity to shape the future of Sandoz and help more patients gain access to low-cost high-quality medicines sustainably.

Our momentum and entrepreneurial spirit is powered by an open collaborative culture driven by our talented and ambitious colleagues who in return for applying their skills experience an agile and collegiate environment with impactful flexible-hybrid careers where diversity is welcomed and where personal growth is encouraged!

The future is ours to shape!

FR : Dans le cadre de sa politique Diversité Evotec étudie à compétences égales toutes les candidatures dont celles des personnes en situation de handicap.

ENG : In the frame of our Diversity policy Evotec considers with equal competences all applications including people with disabilities.