Executive Director, Global Project Leader Hematology Oncology

At AstraZeneca we are committed to advancing the science of oncology to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology Tumor Drivers and Resistance DNA Damage Response Antibody-drug Conjugates Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of cancers we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of currently have nearly 100 Phase 1 2 3 and Lifecycle Management Oncology projects in our robust pipeline. We deliver the Research & Development for Oncology through our Oncology R&D Unit. This unit has responsibility for the value chain from discovery through to late-stage development enabling rapid acceleration of promising early-stage assets and life-cycle management programs.

The Hematology Research and Development (R&D) team is accountable for all drug development activities in hematology research from discovery first-in-man studies all the way to late-stage clinical trials leading to drug approval by regulatory agencies. The team strives to deliver compelling preclinical clinical and translational data packages providing confidence in the dosing strategy tolerability profile and therapeutic efficacy of our candidate drugs to support investment in late-stage clinical development leading to drug approval.

We are looking for a highly qualified candidate to lead the development and execution of the product strategy for one or more projects. This individual will be accountable for the strategic leadership and execution and act as the champion for the product candidates. The individual will develop a range of strategic and tactical options secure governance and budget approval secure cross-functional resources for the projects and then take accountability for execution monitoring and reporting of progress/issues. The individual will articulate the project goals strategy and the underlying science and clinical need to internal and external audiences with clarity and credibility.

In this role the candidate will work with other project leaders scientific and clinical leaders and external experts to develop coordinated project plans that can be delivered across functional boundaries. The candidate will ensure that diverse views within the team are heard and a strongly empowered and motivated team is crafted and will demonstrate highly visible leadership within the oncology community both within AZ and externally. The successful candidate will have hematology/oncology clinical drug development experience demonstrated leadership and be able to critically navigate the science that underlies these programs. The candidate should be able to effectively communicate across a broad range of audiences and can clearly articulate project-specific strategies as well as the overall oncology strategy.

Major Duties and Responsibilities:

• Leads product development teams responsible for novel Hematology Oncology therapies from preclinical lead optimization and candidate selection through Clinical Phase 1 2 and 3 Phase 3 investment decisions and delivery of these studies. The candidate will lead all regulatory for the strategy and execution of a portfolio of pre-clinical and clinical-stage therapies.

• Accountable for the delivery of projects according to quality time budgets and resources

• Build strategic and coordinated product development plans that are aligned with business objectives and are differentiated from competitor products.

• Accountable for the execution of the coordinated product plan to the agreed scope timelines and budgets

• Leads and communicates the project development strategy at governance meetings accountable for aligning with internal management and for communicating with external collaborators.

• Responsible for all aspects of project strategy including preclinical translational clinical development patient selection regulatory pediatric intellectual property CMC and Asian development strategy

• Development of the Target Product Profile ensuring alignment with disease area strategy and late-stage development

• Leads the Global Project Team (GPT) to effectively manage/mitigate/communicate risk make decisions and handle conflict and change.

• Responsible for maintaining a high degree of GPT effectiveness through collaboration influence and as necessary coaching and mentoring of cross-functional team members.

• Ensure that there are robust processes plans and data to enable Governance Bodies to make investment decisions and prioritize projects across the portfolio.

Requirements/Qualifications:

• M.D. or Ph.D. with minimum of 8 years of industry experience

• Experience in drug development including experience in early and late phase drug development and regulatory knowledge.

• Strong knowledge and understanding of the Hematology-Oncology therapeutic area with experience in diverse biological mechanisms and therapeutic modalities.

• Broad understanding of the evolving clinical landscape in hematology/oncology with experience in planning execution and submission of pivotal studies.

• Own the overall development of project strategy and be accountable for project plans timelines progress and outcomes.

• Proven experience leading and motivating teams in a highly matrixed environment.

• Consistent record of cultivating and leading internal and external cross-functional collaborations

• Demonstrated organizational and project management skills

• Proven success in influencing colleagues and senior leaders in various departments.

• Must demonstrate high integrity.

Why AstraZeneca

At AstraZeneca were dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. Theres no better place to make a difference in medicine patients and society. An inclusive culture that champions diversity and collaboration and is always committed to lifelong learning growth and development. Were on an exciting journey to pioneer the future of healthcare.

So whats next

• Are you already imagining yourself joining our team Good because we cant wait to hear from you.

• Are you ready to bring new insights and fresh thinking to the table Brilliant! We have one seat available and we hope its yours.

Where can I find out more

Follow AstraZeneca on LinkedIn AstraZeneca on Facebook AstraZeneca on Instagram annual base pay ranges from 246070 - 369104.Hourly and salaried non-exempt employees will also be paid overtime pay when workingqualifying overtime pay offered may vary depending on multiple individualized factors including marketlocation job-related knowledge skills and addition our positions offer a short-term incentive bonusopportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles)to receive aretirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included aqualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits includingmedical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicableplans. Additional details of participation in these benefit plans will be provided if an employee receives an offer ofemployment. If hired employee will be in an at-will position and the Company reserves the right to modify basepay(as well as any other discretionary payment or compensation program) at any time including for reasons related toindividual performance Company or individual department/team performance and market factors.