Scientist II/Senior Scientist I, LNP Process Development
Scientist II/Senior Scientist I, LNP Process Development
Posted on :
04-06-2025
Employer Active
1 Vacancy
Job Alert
You will be updated with latest job alerts via emailValid email field required
Send jobs
Share
Send me jobs like this
Job Alert
You will be updated with latest job alerts via emailValid email field required
Send jobs
Job Description
OPPORTUNITY
Mammoth Biosciences is seeking a highly motivated Scientist II or Senior Scientist I to join our CMC team in a hands-on cross-functional role that blends scientific ingenuity with operational excellence. This position is critical for developing optimizing scaling and characterizing LNP-based delivery production processes for Mammoths cutting-edge gene editing platforms. The ideal candidate will thrive at the interface of process development analytics and manufacturingsomeone who can transition smoothly between the bench and discussions with external partners. This is a great opportunity to play a key role in advancing transformative gene editing therapies into the clinic and beyond.
KEY RESPONSIBILITIES
- Design and optimize LNP manufacturing processes by applying Quality by Design (QbD) principles and execute Design of Experiments (DoEs) to identify and control critical process parameters (CPPs)
- Optimize analytical methods such as DLS Ribogreen HPLC-CAD IP-RP-HPLC and endotoxin to identify and access critical quality attributes (CQAs)
- Interpret analytical data to assess process robustness and guide iterative development efforts
- Collaborate with internal teams to support process improvements and drive innovation
- Clearly present scientific findings and project updates in internal meetings and to external collaborators
- Drive technology transfer activities with external CDMO partners by preparing comprehensive technical documentation such as development reports process summaries and tech transfer packages to ensure successful external manufacturing
- Stay current with emerging trends in LNP technologies and contribute to strategic process improvements
- Track inventory plan experiments and contribute to an organized quality-focused lab environment
REQUIRED QUALIFICATIONS
- Ph.D. in Chemical Engineering Bioengineering Pharmaceutical Sciences Chemistry or a related field with minimum of 3 years relevant industry experience; or M.S. with 6 years; or B.S. with 8 years
- Demonstrated expertise in LNP formulation and process development including hands-on experience with microfluidic and high-shear mixing technologies tangential flow filtration and dead-end filtration
- Proficiency in analytical characterization techniques for LNPs including DLS fluorescence-based assays and HPLC/UPLC methods (CAD UV IP-RP SEC IEX) including method development troubleshooting and data interpretation
- Experience with in-process and drug product stability studies
- Proven success in applying DoEs and statistical analysis tools for process optimization
- Experience supporting technology transfer of processes to external manufacturing environments with a strong understanding of tech transfer best practices
- Demonstrated strong organizational skills
- A self-starter with demonstrated strong troubleshooting skills capable of driving projects independently while contributing effectively in a collaborative multidisciplinary environment
PREFERRED QUALIFICATIONS
- Knowledge of regulatory expectations for CMC development
- Familiarity with high-throughput screening methods
- Exposure to cell-based assays for LNP functional characterization
- Familiarity with data analysis tools and statistical methods such as JMP
- Experience with AAV vector process development or a strong interest and adaptability to learn viral delivery systems
BENEFITS
- Company-paid health/vision/dental benefits
- Unlimited vacation and generous sick time
- Company-sponsored meals and snacks
- Wellness caregiver and ergonomics benefits
- 401(k) with company matching
Base Salary Range: $157000 - $178000 per year
Actual base salary will be determined by relevant professional experience applicable skills and internal equity.
COMPANY
Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin Janice Chen and Lucas Harrington the companys ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks including base editing gene writing and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoths deep science and industry experience along with a robust and differentiated intellectual property portfolio have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.
It is our policy and intent to provide equal opportunity to all persons without regard to race color religion political affiliation sex/gender (including gender expression/identity pregnancy childbirth and related medical conditions) marital status registered domestic partner status sexual orientation age ancestry national origin veteran status disability medical condition genetic characteristics and/or any other basis protected by law. This policy covers all facets of employment including but not limited to: recruitment selection placement promotions transfers demotions terminations training and compensation.
Mammoth Biosciences requires that all employees be vaccinated against COVID as a condition of at-will employment with exceptions for medical or religious reasons in compliance with local state and federal law.
Required Experience:
Senior IC
Employment Type
Full-Time
Report This Job
Disclaimer: Drjobpro.com is only a platform that connects job seekers and employers. Applicants are advised to conduct their own independent research into the credentials of the prospective employer.We always make certain that our clients do not endorse any request for money payments, thus we advise against sharing any personal or bank-related information with any third party. If you suspect fraud or malpractice, please contact us via contact us page.
