Principal Full Stack AI Engineer
Boston, MA - USA
Job Summary
Job Description
Position Summary
Vertex is seeking anAI Full-StackEngineer to create the next generation of AI-powered applications andagents that deliver practical value across internal and user-facing experiences.This role will own solutions end to endfrom user experience and application services to agent orchestration data access platform integration deployment and production operations.
The ideal candidatecombinesstrongfull-stack softwareengineeringfundamentals with hands-on experience building AI-enabled products.This individual will use a forward deployed engineering mindset to work closely with stakeholders rapidly iterate on real-world use cases connectapplications andagents toenterprisesystems and continuously improve quality through measurement and feedback.The AI Full-StackEngineer willhelp shapehowsecure reliable and scalable AI solutionsare adopted across Vertex.
Key Responsibilities
Designbuild and productionizefull-stackAIapplicationsagentsand multi-step workflows for internal and user-facing use cases
Apply a forward deployed engineering approach by working closely with end users product teams and business stakeholders to solve real workflow problems quickly and effectively
Build agents that can reason across steps invoke tools call APIs retrieve information and take actions within defined enterprise guardrails
Own end-to-end solution delivery across user interfaces application services APIs data access agent orchestration and integrations with internal platforms third-party applications and business-critical systems
Develop reusable agent patterns components prompts tools and orchestration logic that can be scaled across use cases
Rapidly iterate on agent behavior based on usage data qualitative feedback evaluation results and operational metrics
Improve agent quality through testing experimentation benchmarking and structured measurement of outcomes
Partner with platform integration data security and product teams to ensure agents are secure reliable maintainable and aligned with enterprise architecture
Help define best practices for agent design tool use fallback behavior escalation paths and human-in-the-loop workflows
Supportthe complete software lifecycle including architecture development integrationdeployment monitoring troubleshooting and optimization in production environments
Contribute to observability practices for agent execution including logging tracing performance tracking and issue analysis
Ensure solutions are designed with security compliance and responsible AI principles in mind
Stay current on emerging patterns frameworks and technologies in generative AI and agentic systems and translate them into practical applications for Vertex
Required Qualifications
Bachelors degree in Computer Science Software Engineering Artificial Intelligence Data Science or a related technical field; equivalent practical experience may be considered
Experience infull-stacksoftware engineering AI engineering machine learning engineering or intelligent application development
Hands-on experience buildingand operating production
Experiencedesigning and delivering end-to-endapplicationsacross front-end back-endAPIs datastores and enterprise systems
Demonstrated experience using AI-assisted software development and autonomous coding agents to design generate test review debug optimize and refactor code across complex enterprise systems.
Deep understanding of AI-native software engineering practices and experienceestablishingstandards governance and best practices for the responsible use of AI coding assistants and software engineering agents across engineering teams
Demonstrated ability to move from prototype to production while balancing speed quality and operational rigor
Experience working directly with users or stakeholders to iteratively refine technical solutions based on real-world needs
Strong problem-solving andsystems-thinking skills
Strong written and verbal communication skills with the ability to work effectively across technical and non-technical teams
Technical Skills Required
Full-stack application development across modern front-end and back-end technologies
Large language model application development
Agentic workflow design and orchestration
Prompt engineering and prompt iteration
Tool use and API integration for AI agents
Multi-step workflow automation
Rapid prototyping andproductionization
Evaluation testing and quality measurement for AI systems
Application logging monitoring and observability
API design service development data modeling and application architecture
Distributed systems and service integration
Secure software development practices
Enterprise application integration
Cloud-based application development
Version control CI/CD and deployment practices
Preferred Skills
Experience using a forward deployed engineering or similar embedded delivery model
Experience building internal copilots assistants or task-oriented AI agents
Familiarity with orchestration frameworks agent runtimes tool-calling architectures and retrieval patterns
Experience integrating with enterprise collaboration tools workflow systems document platforms or knowledge repositories
Familiarity with evaluation frameworks for AI qualitygroundedness task completion and reliability
Experience designing human-in-the-loop workflows and safe failure or escalation mechanisms
Exposure to AI observability tracing and operational analytics
Experience in regulated industries such as biotechnology pharmaceuticals healthcare or life sciences
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Pay Range:
$166640 - $250000Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors including skills competencies experience and other job-related factors permitted by law.
At Vertex our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career financial family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter) educational assistance programs including student loan repayment a generous commuting subsidy matching charitable donations 401(k) and so much more.
Flex Designation:
Hybrid-Eligible Or On-Site EligibleFlex Eligibility Status:
In this Hybrid-Eligible role you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Hybrid
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at
Required Experience:
Staff IC
About Company
Vertex Pharmaceuticals invests in scientific innovation to create transformative medicines for people with serious diseases.