Biologics Process Research & Development , Senior Scientist

Job Description

Biologics Process Research & Development (BPR&D) within our Companys Research Laboratories is on a mission to rapidly deliver biotherapeutics to patients by efficiently developing innovative robust manufacturing processes and technologies. To achieve this we work closely with colleagues in Discovery Pre-clinical Early Development Analytical Formulation and Commercial Manufacturing while providing an inclusive environment for all. Beyond process development for pipeline biologics we innovate and build next generation biomanufacturing technologies. Examples include investments for development of continuous manufacturing green and sustainable processes and proprietary technology platforms. We actively publish and engage with the scientific community to influence the field.

Biologics Process Research & Development (BPR&D) includes three lab-facing technical functional areas: Process Cell Sciences (PCS) Upstream and Downstream Process Development & Engineering. The latter two together form our Biologics Process Development (BPD) group. This job posting covers opportunities for the BPD group. We are actively looking for highly motivated people with a passion for innovation and interest in contributing to upstream and/or downstream bioprocessing.

Responsibilities include but are not limited to:

• Innovation

  • Develop innovative and disruptive technologies for next-generation biologic manufacturing processes

  • Apply rigorous scientific principles and data analyses to solve challenging problems related to developing robust cost-effective processes

• Experimental Design and Problem-Solving

  • Develop and characterize robust processes for delivering multi-kilogram quantities of life-changing medicines

  • Design and conduct lab and/or pilot-scale studies to support mechanistic understanding scale-up and transfer of processes to manufacturing

• Collaboration and effective communication:

  • Work with a collaborative cross-functional team of talented scientists and engineers to advance the biologics pipeline from early- to late-stage development

  • Partner with groups in both research and manufacturing divisions

  • Represent your functional area in cross-functional teams

• Coaching and Mentoring

  • Train and mentor junior scientists in experimental design execution and data interpretation

• Safety and Compliance

  • Contribute to a safe and compliant laboratory work environment

MINIMUM EDUCATION REQUIREMENTS:

• Bachelors Degree with 4 years or Masters Degree with 3 years or PhD with 0 years of relevant experience (or expected PhD graduation within 6 months from date of application) in Chemical Engineering Biochemical Engineering Biomedical Engineering Biotechnology Biochemistry Biology Microbiology or related fields

REQUIRED EXPERIENCE AND SKILLS:

• A proven ability to design and execute hands-on lab and/or in silico experiments

• Proficiency with statistical design and analysis tools

• Excellent communication skills ability to work in matrixed teams and collaborate with partners cross-functionally

• A demonstrated ability to think critically with excellent problem solving and troubleshooting skills

In addition to the required skillsets above relevant experience is needed in either upstream and/or downstream bioprocessing as described below.

Upstream

• Knowledge of recombinant protein expression metabolic pathways biochemistry and cell culture

• Understanding of basic bioreactor principles mass transfer kinetics

• Understanding of cell & molecular biology

Downstream

• Sound scientific knowledge of protein properties and purification

• Understanding of unit operations such as chromatography filtration crystallization precipitation adsorption mixing etc.

PREFERRED EXPERIENCE AND SKILLS:

• History of external presentations and/or publications in peer-reviewed journals

• Data science modeling machine learning and artificial intelligence; proficiency with programming languages

• Evaluating and introducing novel technologies and analytical tools in process development and manufacturing

• Knowledge of protein biochemistry biophysics conjugation techniques

• Vector construction Genetic Engineering and Systems Biology

• Knowledge of cell-line development for protein expression in mammalian systems and suspension cell culture

• Hands-on experience with RNA and whole-genome (re)sequencing and bioinformatics analysis

• High throughput experimentation using automation platforms

• Familiarity with feed and media development for large-scale recombinant protein expression in mammalian systems

• Knowledge of Quality by Design Process Characterization and Control Strategy development

#BPRD #PRD

Required Skills:

Preferred Skills:

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Effective September 5 2023 employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week Monday - Thursday although the specific days may vary by site or organization with Friday designated as a remote-working day unless business critical tasks require an on-site Hybrid work model does not apply to and daily in-person attendance is required for field-based positions; facility-based manufacturing-based or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.

The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

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