Postdoc Research Scientist, Ion Mobility Mass Spectrometry (IM-MS) and Capillary Electrophoresis MS (CE-MS) (2 years)

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Postdoc Research Scientist Ion Mobility Mass Spectrometry (IM-MS) and Capillary Electrophoresis MS (CE-MS) (2 years)

Johnson & Johnson Innovative Medicine (J&J IM) develops treatments that improve the health of people worldwide. Research and development areas encompass cardiopulmonology immunology communicable diseases neuroscience and oncology. Our goal is to help people live longer healthier lives. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market from patients to practitioners and from clinics to hospitals. To learn more about J&J Innovative Medicine visit https:// Translational ADME Biotransformation team in Beerse Belgium is looking for a highly motivated Postdoctoral Research Scientist (2 years contract) to lead and conduct experimental studies on conformational analysis of small and large molecules using ion mobilitymass spectrometry (IM-MS) and capillary electrophoresis-mass spectrometry (CE-MS). The candidate will design and execute experiments to probe conformational information develop and optimize IM and CE separations analyze complex datasets and contribute to method development for structural and analytical applications.

We are a highly motivated team with state-of-the-art laboratories. The project will be part of broader interdisciplinary research with close interaction and collaboration with scientists across multiple areas of expertise.

Key Responsibilities

• Design and execute experiments using IM-MS and CE-MS for small molecules (metabolites lipids) and larger molecules (peptides PROTACs).

• Optimize ionization conditions CE separations and IM parameters to resolve conformers and isobaric species.

• Maximize the output from raw data using appropriate software and statistical analysis tools.

• Develop and implement data-processing pipelines (scripting and/or software tools) for Collision Cross Section (CCS) extraction peak deconvolution and statistical analyses.

• Collaborate within multidisciplinary teams to contextualize data within broader research objectives propose and develop follow-up experiments and document and present findings.

• Stay updated on advancements in mass spectrometry and related technologies. Implement new technologies and methods to enhance sensitivity data quality and throughput.

Qualifications

• PhD in Analytical or Medicinal Chemistry Pharmaceutical Sciences Biochemistry or a related field

• Very strong organic chemistry background and a solid understanding of molecular structure

• Strong hands-on experience with ion mobility-high-resolution mass spectrometry

• Demonstrated knowledge of gas-phase ion behavior conformational analysis and CCS concepts.

• Proficiency in data analysis software and ability to interpret complex datasets

• Practical experience with capillary electrophoresis coupled to mass spectrometry or equivalent front-end separations is an asset.

• Strong track record of scientific contributions (peer reviewed publications patents or presentations at major meetings) is a plus

• Proficiency in data analysis and scripting (Python R MATLAB or similar) to process large MS/IM datasets is an asset

• Good understanding of NMR data analysis and interpretation

• Strong problem-solving skills attention to detail and ability to work independently and in teams.

• High level of flexibility creativity and sense of responsibility

• Team player with strong interpersonal skills in an international team setting

• Strong communication skills in English both written and verbal

What We Offer:

• Competitive salary and benefits package

• Opportunities for professional development in an exciting R&D environment

• Collaborative and inclusive work environment

• Access to state-of-the-art technology and resources

Required Skills:

Preferred Skills:

The anticipated base pay range for this position is:

Benefits:

In addition to base pay we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location where the actual amount is based on the employees and companies performance of the previous calendar year or sales commissions. Moreover we offer vacation days parental leave for a minimum of 12 weeks bereavement leave caregiver leave volunteer leave well-being reimbursement programs for financial physical and mental health. We also offer service anniversary and recognition awards and subject to the terms of their respective plans employees - and in some locations eligible dependents - can participate in several insurance plans. For more information visit Employee benefits Supporting well-being & career growth Johnson & Johnson Careers.

*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.