Senior Director, Portfolio Excellence and Transformation

AstraZeneca

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profile Job Location:

Gaithersburg, MD - USA

profile Monthly Salary: $ 206993 - 310490
Posted on: 16 hours ago
Vacancies: 1 Vacancy

Job Summary

Senior Director Portfolio Excellence and Transformation

Gaithersburg MD

Global Portfolio & Project Management

Hybrid Work- on average 3 days/week in office

Gaithersburg is the preferred location for thisrolehowever applicants from Cambridge BostonBarcelonaand Mississauga will also be considered.

AstraZeneca Oncology is leading a revolution to redefine cancer care with a portfolio of launched products providing transformative outcomes for patients around the world and a full suite of modalitiesfuellingfuture innovative Global Portfolio and Project Management (GPPM) we play a critical role in advancing the pipeline by closely partnering with Research & Development Commercial and Operations to support decision-making project management resourcemanagementand governance across the AstraZeneca portfolio. Come join a team-oriented and fast-paced environment that requires integrity problemsolvingand agility!

The Senior Director Portfolio Excellence & Transformation is a senior enterprise leadership role created to fundamentallyimprovehowGPTs deliverat scaleto helpacceleratethe Oncology pipeline.Thisis a transformation role for someone who can see what is possible build the case for change and bring people with them. Reporting to the Head of Oncology Portfolio Strategy and Management this individual will lead the Portfolio Excellence and Innovation agenda across GPPM Oncology defining where AI advanced analytics and modern ways of working can create the greatest step-change inGPT ways-of-workingportfolio decision-making process quality and organisational efficiency and expand the impact to other TAs where appropriate. They will translate that ambition into reality through collaboration influence and a focus on impact.

What youll do

Portfolio Excellence and Innovation Strategy

  • Define and own the Portfolio Excellence and Innovation agenda for GPPM Oncology setting a clearprioritisedvision for where AI analytics and process transformation will deliver the greatest impact

  • Identifyhigh-value opportunities across the drug development and portfolio management lifecycle from decision support and scenario modelling to process simplification and capability building and drive the delivery of high-impact initiatives

  • Stayclosely connectedto the externallandscape bringingin emerging thinking technologies and best practice to continuously improve how GPPM can deliver

AI-Enabled Transformation

  • Lead the design piloting and scaling of AI-enabled capabilities that improve the speed quality and consistency ofGPT ways-of-working andEnterpriseportfolio decision-making

  • Partner with Digital Data Science IT GlobalBusinessServicesandR&Dteams to co-develop solutions that are robust scalable and embedded into day-to-day ways of working

  • Drive adoption through demonstrated value clear communication building genuine enthusiasm fornew approachesacross theorganisation

  • Establish guardrails and governance to ensure AI innovation improves decision quality and accountability

Process Excellence and Simplification

  • Lead identification and delivery of high-value simplification opportunities acrossGPTportfolio and business cycle processes reducing complexity duplication and friction

  • Work with GPPM leads and business partners to challenge existing ways of working and build the case for redesign

  • Embed a continuous improvement approach across the team creating frameworks that enable ongoing evolution rather than one-time fixes

Enterprise Influence and Capability Building

  • Operate as an enterprise-level influencer building partnerships across Oncology GPPM and beyond to drive adoption ofnew approachesat pace and scale

  • Build capability across GPPM and partner teams through coaching toolkits and success stories that make innovation tangible and accessible

  • Represent GPPM Oncology in cross-enterprise forums related to digital transformation AI governance and portfolio management capability

Essential for the role

  • Bachelors degree in Science BusinessFinanceor similar subject

  • 10 years of experience in a global biopharmaceutical environment with deep understanding of drug development portfolio management and enterprise business cycles and direct experience working with R&D cross-functional teams

  • Proventrack recordof leading and delivering enterprise-level transformation with measurable lasting impact

  • Proven ability to bridge business and technical domains credible with both senior business leaders and technical specialists acting as an effective translator between the two. Youll understand the business deeply can speak the language of technology without being defined by it and know how to move a large complex organisation from where it is to where it needs to be.

  • Exceptional influencing skills and ability to mobilise cross-functional teams of various skills and capabilities and drive delivery

  • Strong prioritisation and strategic thinking ability toidentifywhere innovation creates the most value and build a compelling case for action

  • Excellent communication skills and ability to simplify complex ideas tell stories that land and build organisational energy around a shared vision

  • A catalyst for ideas for adoption for lasting change andthe ability to bring stakeholders on a journey from awareness to conviction to action

Desirable for the role

  • Advanced degree in a scientific field and/or MBA

  • Direct experience designing or deploying AI or advanced analytics solutions in a drug development or portfolio management context

  • Track recordof building and developing high-performing teams in an innovation or transformation context

Office Working Requirements

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing -person working gives us the platform we need to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay for this position ranges from $206993.60 - 310490.40 USD. Our positions offer eligibility for various incentivesan opportunity to receive short-term incentive bonuses equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs paid time off (i.e. vacation holiday and leaves) as well as health dental and vision coverage in accordance with the terms of the applicable plans.

#LI-Hybrid

Date Posted

07-May-2026

Closing Date

20-May-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.


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Senior Director Portfolio Excellence and TransformationGaithersburg MDGlobal Portfolio & Project ManagementHybrid Work- on average 3 days/week in officeGaithersburg is the preferred location for thisrolehowever applicants from Cambridge BostonBarcelonaand Mississauga will also be considered.AstraZen...
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AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more

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