Research Fellow Computational Cardiology Research, Honigberg Lab, MGH Cardiovascular Research Center

Site: Massachusetts General Physicians Organization Inc.

Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a not-for-profit we support patient care research teaching and community service striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

The laboratory of Dr. Michael Honigberg at the Massachusetts General Hospital Cardiovascular Research Center (CVRC) and Broad Institute of MIT & Harvard has a unique post-doctoral fellow position open for a highly qualified applicant interested in investigation at the intersection of cardiovascular reproductive and aging biology. The new hire will be appointed as a Research Fellow at the Massachusetts General Hospital and Post-Doctoral Fellow at Harvard Medical School.

The Honigberg lab aims to advance mechanistic understanding of emerging cardiovascular risk factors and inform new paradigms for health promotion and disease prevention. Current projects focus on pregnancy (e.g. preeclampsia/eclampsia) menopause aging biology and novel lipid-modifying therapies among other topics.

This position will enable access to resources and opportunities across multiple world-class institutions. Individuals will work with a range of data types including genetic datasets including genotype arrays whole exome and whole genome sequencing single-cell sequencing and multi-omic data (e.g. metabolic transcriptomic proteomic methylation). The successful candidate will work within a dynamic and highly collaborative environment alongside computational biologists bioinformaticians epidemiologists clinicians research coordinators students and medical trainees.


PRINCIPAL DUTIES AND RESPONSIBILITIES:

The successful candidate will work closely with Dr. Honigberg members of the Honigberg Lab and other trainees and faculty at the MGH CVRC and Broad Institute. The successful candidate will be closely supervised by Dr. Honigberg. The successful candidate will have robust facility in computational genetics and bioinformatics. Projects will range from genomic discovery and in silico investigations of genetic mechanisms of disease risk prediction phenotype curation using electronic health record data multi-omic analysis and Mendelian randomization for causal inference.

Overall this is a unique opportunity to engage in cutting edge science and make a central contribution to biomedical addition MGH and the Broad Institute provide vibrant research environments with close links to top academic and industry networks across the Greater Boston area and the world.

Key Responsibilities

Construction and implementation of cloud-based pipelines for genomic polygenic risk scoring and biostatistical analyses.
Processing and quality control of next-generation sequencing data.
Processing and quality control of multi-omics data.
Statistical analyses of genotype-phenotype association analyses with summarization and graphical representations.
Organizing manipulating and harmonizing new datasets across different formats and synchronization with existing datasets and databases.
Phenotypic curation from electronic health record structured and unstructured data.
Construction implementation and sensitivity analyses of biostatistical models in classical epidemiology genetic epidemiology and machine learning.
Lead and contribute to manuscript preparation as well as internal and external project-team reports.
Actively participate and present in project meetings and lab meetings.


SKILLS & COMPETENCIES REQUIRED:

Doctoral degree in computational biology biomedical informatics biostatistics statistical genetics genetic epidemiology or computer science.
First (or co-first) author of one or more peer-reviewed scientific publications.
Excellent English verbal and written communication skills.
Able to work both independently and in a team.
Strong record of productivity motivation adaptability and collaboration.
Exceptional oral and written communication skills.
Strong background in computational biology and bioinformatics.
Strong skills in statistical analyses are highly preferred.
Strong demonstrable proficiency in UNIX R Python and Perl; facility with Java Matlab C C preferred.
Strong facility with cloud computing.
Prior experience in human genetic analyses and bioinformatics analyses of publicly available datasets.
Familiarity with next-generation sequence data analysis tools strongly preferred.
Ability to adapt to rapidly changing and high-demand environments.
Knowledge of cardiovascular disease is not required.

Qualified candidates should send a CV a cover letter and contact information for three references to Dr. Michael Honigberg ().

Find out more about our labs research:

The expected annual salary range will be commensurate with the candidates experience and qualifications and institutional guidelines.

Review of applications will begin immediately and continue until the position is filled.

EEO Statement
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills perspectives and ideas we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.

Job Summary

Summary


Does this position require Patient Care
No

Essential Functions

Education

Can this role accept experience in lieu of a degree

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Physical Requirements

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1300 Massachusetts General Physicians Organization Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religious creed national origin sex age gender identity disability sexual orientation military service genetic information and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973 the Vietnam Veterans Readjustment Act of 1974 and Title I of the Americans with Disabilities Act of 1990 applicants who require accommodation in the job application process may contact Human Resources at .

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