Postdoctoral Fellow-MSH

Title: Postdoctoral Fellow Organic Synthesis and Medicinal Chemistry

Salary: $75000

Department: Pharmacological Sciences

Physical work location: Icahn Medical Institute 1425 Madison Ave. NY NY 10029

Name PI or Supervisor: Professor Robert J. DeVita Ph.D.

Web link to Lab: link to Department: Contact: Yoori Kim 212-

Details of Research Project: The DeVita Lab of the Drug Discovery Institute and Dept of Pharmacological Sciences pursues novel drug targets in collaboration with clinicians and PI labs at Mt Sinai as a collaborative approach for translational science to develop new therapeutics for unmet medical needs. Active projects include projects directed to treat diabetes IBD/Crohns disease cancer and rare genetic diseases.

Educational and other Requirements for the position:

PhD in organic synthesis required with knowledge of heterocyclic chemistry organometallic chemistry and structure-based drug design using the Schrodinger suite desired.

Technical Duties: (include any protocols):

The role will require synthesis of novel medicinal compounds for testing in in vitro and in vivo assays that support the basic biology translational science and drug discovery research efforts.

Experience Required:

Preparation purification and characterization of compounds in chemistry laboratory; documentation of all experiments in electronic lab notebooks (ELN) including written publication quality experimental procedures. Operation and maintenance of laboratory instruments - HPLC and LC-MS for example. Safe laboratory habits and experimental practices. Strong collaboration skills with chemistry team members and biology collaborator labs.

Essential Skills

Strong background in organic chemistry in the area of organic synthesis heterocyclic and organometallic chemistry; compound purification characterization using NMR spectroscopy and analysis of reaction products using TLC and LC-MS techniques; methodology development; design of novel analogs; design and testing of synthetic routes to desired novel compounds. Competence in Schrodinger suite of software for structure-based drug design and ligand docking is desired. 90% in lab medicinal chemistry; 10% structure-based drug design.

Preferred Knowledge Skills and Capabilities

Earned doctorate in organic chemistry with specific experience in total synthesis heterocyclic and organometallic chemistry; demonstrated experience in the synthesis purification and analysis of complex organic molecules; experience with new method development rapid analog and library synthesis techniques; multi-step synthetic processes and larger multi-gram reaction scale-up. Microwave assisted synthesis. Excellent reaction trouble shooting skills. Experience with the safe handling of reactive and air-sensitive materials. Characterization of new molecules by NMR and LC-MS.

Competence with Schrodinger suite of software for structure-based drug design and ligand docking is desired with training available for those with an interest to learn this capability. Excellent English written and oral communication skills. Ability to prepare and document experimental procedures for manuscript submission patent applications with journal quality submission.

Goals/Outcomes of the Research Project: Development of small molecules as potential therapeutics for unmet medical needs. Patent applications and publications resulting from the small molecule drug discovery medicinal chemistry efforts.

858 - Pharmacological Sciences - ISM Icahn School of Medicine