Postdoctoral Research Fellow, Anesthesiology

full-time

Pay Range

This Postdoctoral Fellow position is essential for the successful execution of a highly technical multi aim translational research project focused on uncovering immune mechanisms underlying chemotherapy induced peripheral neuropathy (CIPN) in the context of breast cancer treatment. The proposed research integrates complex orthotopic tumor models immune specific genetic manipulations advanced neurobehavioral phenotyping and translational pharmacologic interventions all of which require a dedicated full time postdoctoral scientist with advanced methodological and analytical expertise.

Scope of the Position and Key Functions
The Postdoctoral Fellow will serve as the primary experimental lead and integrator across all three Specific Aims of the project with responsibilities including but not limited to:
1. Experimental Design and Execution
Lead and coordinate immunocompetent orthotopic breast cancer resection models combined with adjuvant chemotherapy.
Execute complex longitudinal CIPN behavioral assays (mechanical allodynia cold sensitivity).
Perform immune specific genetic and pharmacologic manipulations targeting the IRE1α XBP1 pathway.
Conduct advanced flow cytometry FACS sorting molecular assays (qPCR ELISA) histology and confocal imaging.
2. Mechanistic and Translational Integration
Integrate tumor progression endpoints (recurrence lung metastases IVIS imaging) with neurotoxicity and immune outcomes.
Perform ex vivo co culture assays linking immune cell activation to neuronal injury and tumor aggressiveness.
Evaluate translational pharmacologic strategies (MKC 8866 paclitaxel) across multiple disease contexts.
3. Data Analysis Interpretation and Dissemination
Analyze high dimensional data across behavioral molecular immune and oncologic endpoints.
Prepare manuscripts conference presentations and progress reports for funding agencies.
Contribute to grant development supporting continuation and expansion of the research program.
4. Research Training and Mentorship
Provide day to day mentorship to trainees (graduate students and research staff) in specialized techniques.
Foster cross disciplinary collaboration between cancer biology immunology neuroscience and anesthesiology.

Our CommitmenttoYou:

Advocate Health offers a comprehensive suite of Total Rewards: benefits and well-being programs competitive compensation generous retirement offerings programs that invest in your career development and so much more so you can live fully at and away from work including:

Compensation

• Base compensation listed within the listed pay range based on factors such as qualifications skills relevant experience and/or training
• Premium pay such as shift on call and more based on a teammates job
• Incentive pay for select positions
• Opportunity for annual increases based on performance

Benefits and more

• Paid Time Off programs
• Health and welfare benefits such as medical dental vision life andShort- and Long-Term Disability
• Flexible Spending Accounts for eligible health care and dependent care expenses
• Family benefits such as adoption assistance and paid parental leave
• Defined contribution retirement plans with employer match and other financial wellness programs
• Educational Assistance Program