Principal Research Associate – Protein Engineering (Contract)

Job Title: Principal Research Associate Protein Engineering

Department: Protein Engineering
Location: On-site - Seattle

Schedule: M-F

Contract Length: 6 momnths with the chance to extend

At Vertex Pharmaceuticals we are relentless in our pursuit of transformative solutions for patients with serious diseases. Our innovative approach to research and development has positioned us as a leader in the biotechnology industry. We are seeking a talented and motivated Principal Research Associate to join our Protein Engineering team and contribute to the advancement of cutting-edge therapeutics.

Position Summary: The Principal Research Associate will play a pivotal role in supporting the Protein Engineering group by driving the progression of molecules from design to functional proteins for downstream testing. The ideal candidate will have a strong background in molecular cloning yeast display and next-generation sequencing (NGS) library preparation. This is an exciting opportunity to work in a collaborative and innovative environment contributing to the development of transformative therapies.

Key Duties & Responsibilities

• Perform molecular cloning techniques including PCR DNA assembly (e.g. Gibson assembly) sequencing and troubleshooting.
• Support the design construction preparation and validation of DNA constructs for protein engineering projects.
• Conduct yeast culturing and transformations to support yeast display workflows.
• Perform flow cytometry to assess yeast-displayed proteins and analyze data to inform decision-making.
• Prepare and perform quality control for next-generation sequencing (NGS) libraries to support protein engineering workflows.
• Collaborate with cross-functional teams to ensure seamless integration of protein engineering efforts with downstream assays.
• Maintain accurate and detailed records of experimental procedures results and data analysis.
• Contribute to the development and optimization of new protocols and methodologies to enhance the efficiency and effectiveness of the Protein Engineering group.

Required Education Level

• Masters Degree (or equivalent degree) in cellular biology biochemistry or bio/chemical engineering and 3 years of relevant industry experience or
• Bachelors Degree (or equivalent degree) in cellular biology biochemistry or bio/chemical engineering and 6 years of relevant industry experience

Qualifications:

• Expertise in molecular cloning workflows and troubleshooting.
• Hands-on experience with yeast culturing and transformations.
• Experience with next-generation sequencing (NGS) library preparation and quality control.
• Proficiency in flow cytometry.
• Experience with yeast DNA library transformation and screening is highly desirable.
• Excellent problem-solving skills and the ability to troubleshoot experimental challenges.
• Strong organizational skills with attention to detail and the ability to manage multiple projects simultaneously.
• Effective communication and collaboration skills to work in a multidisciplinary team environment.

$63-$67/HR

This job posting is for a temporary role with a third-party agency partner on assignment at Vertex Pharmaceuticals (Vertex). The individual selected for this role will be offered the role as an employee of a third- party agency partner; compensation medical benefits fringe benefits and other terms and conditions of employment shall be presented by the third-party agency partner upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on a number of factors including skills competencies experience location and/or being pursued and other job-related factors permitted by addition this role will be eligible for overtime pay in accordance with federal and state requirements

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