Senior Machine Learning Scientist, Drug Discovery Analytics

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The companys RAS(ON) inhibitors daraxonrasib (RMC-6236) a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291) a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805) a RAS(ON) G12D-selective inhibitor; and RMC-5127 a RAS(ON) G12V-selective inhibitor are currently in clinical development. As a new member of the Revolution Medicines team you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking a Senior Machine Learning Scientist to help accelerate drug discovery through advanced analytics and artificial intelligence. This role will develop predictive models and analytical methods that transform complex biological and chemical datasets into actionable insights that guide research decisions.

The Senior Machine Learning Scientist will work at the interface of data science chemistry and biology to support target discovery compound optimization and translational research. This position requires both strong machine learning expertise and the ability to collaborate effectively with experimental scientists to solve real-world scientific problems.

The successful candidate will contribute to building a data-driven discovery ecosystem where data analytics and experimentation continuously inform and accelerate one another.

Key responsibilities include:

Develop Predictive Models for Drug Discovery

• Design and implement machine learning models to predict compound activity selectivity and developability.

• Develop predictive frameworks for ADME/Tox target engagement and phenotypic screening outcomes.

• Apply advanced modeling approaches including deep learning graph neural networks and ensemble methods.

• Evaluate model performance and apply appropriate validation strategies.

• Work with data engineers and ML engineers to integrate models into discovery pipelines.

Analyze Complex Scientific Data

• Perform exploratory data analysis on chemical biological and phenotypic datasets.

• Integrate heterogeneous datasets including:

• Chemical structure and screening data.

• High-content imaging data.

• Structural biology and molecular simulation outputs.

• Identify patterns and relationships that inform scientific hypotheses.

Collaborate with Research Scientists

• Partner with medicinal chemists to support compound design and lead optimization.

• Work with biologists to interpret experimental results and identify new target opportunities.

• Translate scientific questions into computational modeling strategies.

Required Skills Experience and Education:

• PhD in machine learning computational biology computational chemistry computer science statistics or a related quantitative field.

• 48 years experience applying machine learning or advanced analytics to scientific datasets.

• Python and scientific computing libraries (NumPy Pandas SciPy).

• Machine learning frameworks (PyTorch TensorFlow scikit-learn).

• Model development validation and evaluation methods.

• Data visualization and exploratory analysis.

• Experience working with noisy and incomplete experimental datasets.

Preferred Skills:

• Cheminformatics or molecular modeling tools (RDKit OpenEye etc.).

• Multi-omics data analysis.

• Cloud computing environments.

• MLOps or scalable model deployment.

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