Senior Director, Molecular Imaging Physicist

At RayzeBio every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb RayzeBio blends the nimble pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here youll join a multidisciplinary team where your ideas are valued your expertise is amplified and collaboration is at the heart of everything we do. From day one expect to make an immediate impacton our science on our teams and most importantly on patients. Learn more about RayzeBio: Sr. Director Molecular Imaging Physicist will be responsible for applying their deep expertise in nuclear medicine molecular imaging (including PET and SPECT instrumentation and quantitative analysis) to drive innovation and ensure the highest standards in both preclinical and clinical programs.

The Sr. Director Molecular Imaging Physicist will lead and coordinate imaging and dosimetry activities across multidisciplinary teams oversee translational dosimetry analysis support clinical studies and manage collaborations with internal stakeholders external vendors and scientific partners. The ideal candidate will execute conventional RPT physics approaches with ease drive deep-learning based innovations with a passion to advance imaging technologies contribute to protocol and strategy development and provide technical support and training all while championing quality practices and regulatory compliance in the adoption of novel radioisotopes and modeling approaches including for alpha-emitting radiotherapeutics.

Job Responsibilities:

Essential duties and responsibilities include the following. Other duties may be assigned.

• Lead and coordinate all aspects of internal dosimetry and quantitative imaging analysis in the discovery and development of radiopharmaceutical imaging and/or therapeutic agents.

• Initiate design and execute imaging strategies for preclinical and clinical studies including protocol development imaging manuals statistical analysis plans and clinical trial reporting.

• Support advanced dosimetric analysis and modeling from imaging modalities (e.g. PET SPECT CT) including kinetic modeling compartmental analysis and physiologically-based pharmacokinetic modeling to assess drug uptake distribution and translation from animal to human.

• Oversee and optimize image data quality control including standardization processes calibration and quality assurance aligned with current industry guidelines and literature.

• Innovate and implement new imaging technologies reconstruction algorithms and modeling approaches to enhance diagnostic accuracy therapeutic efficacy and radiopharmaceutical development including novel radioisotopes (e.g. alpha-emitters).

• Manage and support relationships with imaging and dosimetry vendors CROs external investigators and government agencies.

• Provide expert technical support training and problem-solving solutions to cross-functional teams throughout the organization.

• Contribute to regulatory activities and the advancement of medical physics knowledge in radiopharmaceuticals.

• Communicate complex imaging and dosimetry topics clearly and concisely to internal and external scientific stakeholders.

• Organize prioritize and deliver on corporate timelines in a dynamic multidisciplinary team environment with minimal supervision.

• Maintain professional ethics integrity leadership and confidentiality and stay current with global dosimetry guidelines and advances in radiopharmaceutical science.

Basic Qualifications:

• Advanced degree in Medical Physics Molecular Imaging Electrical Engineering or related discipline with didactic training in dosimetry-enabling image-quantification

• Minimum of 7 years of experience in industry in a cross-functional matrix environment.

• Minimum of 2 years of experience in radiopharmaceutical diagnostics and therapeutics development in oncology experience with alpha-emitters strongly desired.

Preferred Qualifications:

• PhD

• Experience with radiopharmaceuticals as diagnostics and/or therapeutics in oncology and experience with alpha-emitters.

• Board certification in nuclear medicine physics or radiation protection.

Skills and Qualifications:

• Subject Matter Expert with extensive experience in radiopharmaceutical development for oncology including theranostic pairs and alpha-emitter technologies able to support all aspects of internal dosimetry analysis including extensive experience with instrumentation (e.g. PET SPECT autoradiography) image reconstruction and clinical applications as appropriate.

• Demonstrated ability to design execute and analyze dosimetry data from preclinical experiments as well as support clinical research involving conventional and advanced imaging innovations leading translational dosimetry data collection and analysis and ensuring data quality control and standardization processes aligned with current literature and global guidelines.

• Passion for advancing medical physics knowledge and pioneering innovative radiopharmaceutical technologies including deep learning-based methods for image reconstruction and evaluation of novel radioisotopes.

• Familiarity with clinical scanner models and experience in developing imaging protocols manuals analysis plans and clinical study reports across phases 1 to 4 trials and providing technical expertise for supporting regulatory submissions.

• Technical proficiency with scanner and dosimetry software image data processing coding and/or simulation modeling and statistical tools such as 3D-RD-S MIM MIRDcalc OLINDA Torch GATE SIMIND SAAM II SimBiology Python C C Matlab R SPSS ITK-snap 3D Slicer Elastix or deep learning-based image reconstruction algorithms.

• Proven track record in managing projects by coordinating cross-functional teams aligning stakeholders and delivering on corporate timelines in a multidisciplinary and dynamic environment.

• Ability to organize prioritize and work effectively with minimal supervision while adapting to a constantly changing environment; recognized leadership skills professional ethics integrity and ability to maintain confidential information.

• Ability to leverage AI to drive programs portfolios or functional performance through prioritization and scaled adoption

• Strong communication skills with the ability to present and discuss complex imaging and dosimetry topics clearly and concisely to global scientific audiences regulatory bodies vendors and internal stakeholders.

• Willingness to travel (up to 10-15%) including participation in conferences industry events and evening/weekend engagements as required.

Physical Demands:

While performing the duties of thisjob the employee is regularly required to sit reach with hands and arms and talk or hear. The employee must occasionally lift and/or move up to 15 pounds. Specific vision abilities required by thisjobincludeclose vision and distance vision.

This is a position that may require working in a laboratory environment protective clothing gloves and safety glasses are required while working in a laboratory environment with radioactive materials.

WorkEnvironment:

The noise level in theworkenvironment is usually moderate.

If you come across a role that intrigues you but doesnt perfectly line up with your resume we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job such as required skills where the job is performed the employees work schedule job-related knowledge and experience. Final individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits please visit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical pharmacy dental and vision care.

• Wellbeing Support: Programs such as BMS Well-Being Account BMS Living Life Better and Employee Assistance Programs (EAP).

• Financial Well-being and Protection: 401(k) plan short- and long-term disability life insurance accident insurance supplemental health insurance business travel protection personal liability protection identity theft benefit legal support and survivor support.

Work-life benefits include:

Paid Time Off

• US Exempt Employees: flexible time off (unlimited with manager approval 11 paid national holidays (not applicable to employees in Phoenix AZ Puerto Rico or Rayzebio employees)

• Phoenix AZ Puerto Rico and Rayzebio Exempt Non-Exempt Hourly Employees: 160 hours annual paid vacation for new hires with manager approval 11 national holidays and 3 optional holidays

Based on eligibility* additional time off for employees may include unlimited paid sick time up to 2 paid volunteer days per year summer hours flexibility leaves of absence for medical personal parental caregiver bereavement and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours depending on the nature of their work and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors leased workers and other service providers are not eligible to participate in the program.

RayzeBio and Bristol Myers Squibb

RayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary of BMS; however RayzeBio will continue to operate as a standalone organization.

Supporting People with Disabilities

BMS and RayzeBio are dedicated to ensuring that people with disabilities can excel through a transparent recruitment process reasonable workplaceaccommodations/adjustmentsand ongoing support in their roles. Applicants can request a reasonable workplaceaccommodation/adjustmentprior to accepting a job offer. If you require reasonableaccommodations/adjustmentsin completing this application or in any part of the recruitment process direct your inquiries to. Visit access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS and RayzeBio will consider for employment qualified applicants with arrest and conviction records pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position please visit this page for important additional information: Protection

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