Manager, Sample Management

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team you will join other outstanding Revolutionariesin a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking a hands-on Manager of Sample Management to lead day-to-day laboratory operations and directly supervise staff within the sample management function. Reporting to the Director of Sample Management this role is ideal for a working leader who enjoys being shoulder-to-shoulder with their team actively directing work troubleshooting issues in real time and ensuring high-quality execution. The successful candidate will combine strong people leadership with deep operational experience in modern sample and compound management environments.

• Provide direct hands-on leadership to sample management staff including daily work assignment prioritization and real-time problem solving.

• Manage and participate in core sample management activities including sample receipt storage tracking retrieval and disposal.

• Ensure smooth day-to-day operation of automated storage systems LIMS and supporting laboratory infrastructure.

• Train mentor and develop staff through on-the-job coaching feedback and performance management.

• Implement maintain and enforce SOPs and best practices for all critical sample management processes.

• Identify and implement process improvements to enhance efficiency reliability and scalability.

• Serve as the primary point of contact for cross-functional partners ensuring timely and accurate delivery of materials.

• Work closely with the Director of Sample Management to communicate capacity risks and resource needs.

• Support onboarding and ramp-up of new staff and technologies within the laboratory.

Required Skills Experience and Education:

• BS/MS or equivalent degree in chemistry biology engineering or a related scientific discipline.

• 5 years experience in sample management compound management or laboratory operations.

• Proven experience directly supervising and leading technical staff in a laboratory environment.

• Hands-on experience with automated sample storage systems LIMS and laboratory automation tools.

• Strong attention to detail operational discipline and commitment to data integrity.

• A proven background in continuous improvement methodologies.

• Comfort operating in a fast-paced collaborative discovery environment.

• Clear and effective written and verbal communication skills.

Preferred Skills:

• Experience supporting small-molecule drug discovery programs.

• Experience training and mentoring early-career scientists or technicians.

• Exposure to process improvement initiatives or system implementations.

• Familiarity with vendor-managed laboratory automation platforms.

• Direct experience with Cenevos Sample Management Software Mosaic.

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