Principal Clinical Bioinformatician (UK)
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Job Summary
Make your mark for patients
We are looking for a Principal Clinical Bioinformatician who is innovative and agile to join our Clinical Bioinformatics Group in Slough UK (Windlesham Surrey from 2027).
About the role
To support generation of insights for clinical assets through understanding of mode of action and treatment effects as seen in patient-level molecular data.
Who youll work with
Working with a high level of autonomy you will report to Head of Clinical Bioinformatics.
What youll do
- With minimal guidance of senior staff processes analyzes and interprets data from omics studies for assets in the clinical portfolio to refine understanding of biological mechanisms disease pathobiology characterise treatment effect safety signals and other relevant insights.
- Develops approaches methods analysis pipelines utilizing state-of-the-art tools and technologies to enable the above.
- Documents code analyses and ensure reproducibility of results according to best practices suited to patient-level data
- Draft reports detailing methods and results that require minimal revision. Drafts / contributes to scientific publications that present the results of these analyses (conference abstracts/presentations and manuscripts).
Interested For this role you need the following education experience and skills
- Master/PhD with 8 years of experience preferably with industry experience.
- Expertise in pre-processing integration and analysis of different omics data types in particular extensive experience analysing large bulk and single-cell RNAseq datasets from complex studies (preferably clinical trials) and experience deriving relevant biological insights from these. Experience with spatial data epigenomics and proteomics is also desirable.
- Expertise in the development and application of methods pertinent for functional interpretation of omics data e.g. pathway enrichment functional module detection causal reasoning.
- Experience analyzing and deriving insights using large omics datasets from clinical trials and relating omics data results to clinical variables is a plus.
- Excellent computational skills such as experience of operating in a HPC Unix environment cloud-based computational and/or pipelining platforms and containerization technologies (e.g. Docker) for reproducible and portable bioinformatics workflows. Experience using DNAnexus is a plus.
- Proficiency using R and other programming languages common to the bioinformatics community. Ability to document code and follow coding best practices in particular suited to patient-level data to ensure reproducibility of results.
- Good understanding of statistics data mining and visualization of biological data types and the standard tools used in these domains.
- Ability to interpret and communicate efficiently (orally and with reports) the outcomes of analytical work to both expert and non-expert scientific audience to foster efficient decision-making. Preferably experience in authoring scientific publications.
Are you ready to go beyond to create value and make your mark for patients If this sounds like you then we would love to hear from you!
About us
UCB is a global biopharmaceutical company focusing on neurology and immunology. We are over 9.000 people in all four corners of the globe inspired by patients and driven by science.
Why work with us
At UCB we dont just complete tasks we create value. We arent afraid to push forward collaborate and innovate to make our mark for patients. We have a caring supportive culture where everyone feels included respected and has equal opportunities to do their best work. We go beyond to create value for our patients and always with a human focus whether thats on our patients our employees or our planet. Working for us you will discover a place where you can grow and have the freedom to carve your own career path to achieve your full potential.
At UCB weve embraced a hybrid-first approach to work bringing teams together in local hubs to foster collaborative curiosity. Unless expressly stated in the description or precluded by the nature of the position roles are hybrid with 40% of your time spent in the office.
UCB is an equal opportunity employer. All employment decisions will be made without regard to any characteristic protected by applicable laws.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Please note should your enquiry not relate to adjustments; we will not be able to support you through this channel.
Required Experience:
Staff IC
Key Skills
- Business Development
- Classroom Experience
- Dayforce
- Go
- Cloud Computing
- AWS
- Teaching
- Administrative Experience
- Leadership Experience
- negotiation
- SAS
- Data Analysis Skills
About Company
UCB – Inspired by patients. Driven by science. At UCB, we put our heart, soul and skills into making a difference for people living with severe diseases. We're here because we want to transform patients’ lives by pushing the boundaries of what is possible.To achieve our ambition, we w ... View more
