Senior Specialist, Computational Toxicology – 18 month secondment fixed term contract

In this role youll partner across R&D and Manufacturing Science & Technology (MSAT) to deliver highquality Extractables & Leachables (E&L) toxicology assessments that meet internal standards and regulatory expectations. Youll work sidebyside with nonclinical safety colleagues vaccine toxicologists and MSAT expertslearning new tools and approaches while shaping submissions that matter.

Key responsibilities

• Provide toxicology assessments for Extractables & Leachables supporting Large Molecules Small Molecules and Vaccines.
• Perform E&L toxicology assessments aligned with R&D scientific standards and ensure appropriate review and documentation prior to final approval.
• Use in silico/(Q)SAR tools (e.g. Derek Nexus Leadscope Toxtree) and expert knowledge to evaluate chemical structures for genotoxicity mutagenicity and other endpoints.
• Locate interpret and critically review nonclinical toxicology data (e.g. genotoxicity carcinogenicity skin sensitisation systemic toxicology) from internal and external data sources and platforms (e.g. ECHA ToxPlanet SciFinder Symphora).
• Summarise in silico and nonclinical evidence highlight the most relevant/robust datasets and calculate permissible daily exposures (PDEs) or acceptable daily intakes (ADIs) to support limit-setting in line with GSK and regulatory expectations.
• Use cheminformatics and predictive tools (e.g. OECD Toolbox Helium Leadscope) to analyse physicochemical and structural properties and to identify surrogate compounds with robust data for readacross.
• Maintain uptodate knowledge of relevant regulatory guidelines (e.g. ICH Q3E ICH Q3C ICH Q3D ICH M7) and incorporate these into assessments.
• Support development or update of internal standards guidance documents safety thresholds processes and training materials related to E&L toxicology strategy.

Why you

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• Degree in toxicology chemistry biology biochemistry pharmacy or related discipline preferred. Advanced degree (MSc PhD or equivalent) is beneficial.
• Experience in pharmaceutical or related industries; handson experience working with toxicology data is preferred.
• Experience interpreting nonclinical toxicology data and familiarity with regulatory guidance relevant to E&L.
• Practical experience with (Q)SAR/predictive tools and cheminformatics is beneficial.

Skills & competencies

• Strong technical writing and datasummary skills (clear concise toxicology reports).
• Attention to detail and high standards for accuracy and documentation.
• Solid quantitative/mathematical competence for exposure and PDE/ADI calculations.
• Effective collaboration and ability to work across multidisciplinary teams.
• Ability to prioritise work at pace and manage workload for fixed-term deliverables.

Closing date for applications: 11th March 2026

Why GSK

Uniting science technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade as a successful growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale.

People and patients around the world count on the medicines and vaccines we make so were committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients accountable for impact and doing the right thing is the foundation for how together we deliver for patients shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race color religion sex (including pregnancy gender identity and sexual orientation) parental status national origin age disability genetic information (including family medical history) military service or any basis prohibited under federal state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at where you can also request a call.

Please note should your enquiry not relate to adjustments we will not be able to support you through these channels. However we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receive

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSKs commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license GSK may be required to capture and report expenses GSK incurs on your behalf in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSKs compliance to all federal and state US Transparency requirements. For more information please visit the Centers for Medicare and Medicaid Services (CMS) website at Experience:

Senior IC