Head of Enterprise Architecture

Closing date:4 March 2026

Contract type:Permanent

Interview dates:W/C 9 March 2026

TheWellcomeTrust is a global charitable foundation. We improve health for everyone by funding science leadingpolicyand advocacy campaigns and building partnerships.

We plan to spend 16bn over the next ten years funding new discoveries in life health and wellbeing and taking on three global health challenges: mental health infectious disease and climate and health.

These challenges need the bold science we support but theywontbe solved by science alone.

Wellcome Trust is seeking a Head of Enterprise Architect to lead and shape the organisations technology landscape providing strategic guidance to the CIO building an enterprise architecture capability and driving simplification governance and innovation across all systems and data.

Where inWellcomewill I be working

You will operate at enterprise level within Wellcome Trust sitting at the heart of the organisations technology landscape. Helping shape the overall enterprise architecture across the organisation.

What will I be doing

You will be defining how technology works across the entire organisation ensuring it is simplified future-ready well-governed and aligned to Wellcomes mission while building the architecture capability from the ground up and advising at executive level.

Is this job for me

Do you have enterprise-level architecture experience and have you led strategic technology initiatives

Have you worked in cross-functional teams influencing senior leadership or Board-level stakeholders

Are you comfortable building a capability from scratch and shaping processes and governance

MinimumCriteria:

• Proven experience implementing enterprise architecture strategies and building architecture capabilities.

• Familiarity with TOGAF or equivalent architecture standards.

• Ability to assess assure and improve the control environment across technology systems.

• Experience leading teams managing budgets and building high-performing inclusive functions.

• Strong technical understanding across multiple domains: applications data integration emerging technologies (AI/ML).

You can view the fullJob Description on our website

You can read more about the benefits we offer our employees onourwebsite

Our HybridWay ofWorking

We understand that our colleagues have commitments and personal interests outside of work and we strive to build a flexible working environment in which people can perform at their best.

At Wellcome we have a hybrid way of working which is 3 days in our Euston Road offices (TuesdayWednesdayand Thursday) with the remaining 2 days working either remotely or in the office.

Diversity and Inclusion is at the heart of everything we do

Diversity and Inclusion is a priority at Wellcome.We are committed to cultivating a fair andinclusiveenvironment where everyone can be themselves and thrive. We are happy to discuss flexible working options for all roles. We work to ensure that our recruitment processes are as inclusive as possible to everyone. This includesmaking adjustmentsfor people who have a disability or long-term condition.

Please visitourwebsitefor more information on adjustments andaccessibility orcontact us at.

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