Scientist II, Process Chemistry

Redwood City, CA - USA

Monthly Salary: Not Disclosed

Posted on: 21 hours ago

Vacancies: 1 Vacancy

Job Summary

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team you will join other outstanding Revolutionariesin a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking a revolutionary team-player with high energy for our dynamic company environment. This position will be responsible for research development and technology transfer of chemical processes to commercial scale. This role is an individual contributor with direct laboratory responsibilities reporting to the Senior Director Process Chemistry.

Responsibilities:

Develop chemical processes through design and execution of laboratory experiments. Design and propose viable alternative chemistry for drug substance and intermediates including route evaluation and process optimization.
Analyze and interpret experimental data to troubleshoot reactions identify anomalies and improve operational efficiency yield and purity of synthetic procedures.
Independently perform multi-step organic syntheses including the purification and characterization of intermediates and final compounds.

Maintain a detailed accurate and up-to-date electronic notebook. Author process development reports as need to support knowledge capture. Present experimental findings and recommendations in team meetings.
Partner with analytical development pharmaceutical development and supply chain functions to maintain overall project timelines.
Author detailed experimental procedures and technical reports to support regulatory filings and internal documentation.
Collaborate with internal and external teams to ensure smooth technology transfer and process implementation at external partners.
International travel to CRO/CDMO for the oversight of development activities and manufacturing (up to approximately 10%).

Required Skills Experience and Education:

PhD in organic chemistry or a related discipline and a minimum of 2-5 years of related experience (may include post-doc); MSc degree in organic chemistry or a related discipline with 8 years of relevant experience or a BS degree in chemistry and a minimum of 10 years of experience in chemical experimentation.
Hands-on experience with detailed reaction analysis in synthetic organic chemistry. Impurity identification with structural elucidation through NMR HPLC and LC-MS for routine analysis is essential.
Written and verbal communication to enable effective and efficient discussions of detailed and complex scientific ideas results and procedures.
Functional data plotting to identify trends and dependencies is a must. High competence with the Microsoft and ChemDraw suites to communicate research results in a compelling manner is expected.

Preferred Skills:

A gifted experimentalist with deep mechanistic curiosity and an ability to push arrows.
An open communicator eager to brainstorm and discuss ideas and experiments
A scientist who appreciates the beauty of a well-designed properly executed experiment.
A curious person who isnt afraid to be wrong and learn from their mistakes.
#LI-Hybrid #LI-CT1

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role level and location. Individual base pay salary is determined by multiple factors including job-related skills experience market dynamics and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed which includes competitive cash compensation robust equity awards strong benefits and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race color religion gender sexual orientation gender identity/expression national origin/ancestry age disability marital status medical condition and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect process and use any personal data that you provide to us in accordance with ourCCPA additional information please contact .

Base Pay Salary Range

$132000$166000 USD

Required Experience: