Principal Scientist, Cell Culture Patient Derived Organoids

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Principal Scientist Cell Culture Patient Derived Organoids

We are looking for a highly motivated scientist with experience in organoid culture and oncology cellular biology to join the Oncology Translational Research team within GSK Oncology Therapeutic Area (TA). The Oncology Translational Research team will partner with Oncology TA team members increase clinical translatability and to contribute to preclinical development programmes within GSK Oncology TA. The successful candidate will work as part of a team that by exploiting patient-derivedorganoids is developing and implementing cutting-edge cellular genomic and molecular techniques with a multimodality analytic approach plus machine learning models to improve cancer patient risk stratification as well as to predict future targeted and/or immuno-therapy susceptibilities.

We value curiosity clear thinking practical problem solving and a focus on impact for patients. This role offers growth the chance to shape new technologies and a direct contribution to GSKs mission of uniting science technology and talent to get ahead of disease together.

In this role you will

• Be involved in the expansion and culture patient-derived organoids independently or in co-culture with other cell types such as immune cells or fibroblasts.

• Perform quality control procedures on patient-derived organoids including evaluating cell density proliferation rates and cytotoxicity as well as carrying out cell culture and expansion.

• Conduct flow cytometry analyses on organoids and other cell types.

• Collect and report experimental data to the laboratory head.

• Collaborate and cooperate with scientists from Kings College London within the GSKKCL Translational partnership.

Why you

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• PhD in Cell Biology/Oncology or related OR a Masters with equivalent experience a multidisciplinary mix of training/expertise in Oncology and Cancer cell biology.

• Significant experience in cell culture techniques (patient-derived organoids immune cells cancer associated fibroblasts) cytotoxicity analysis.

• Flow cytometry experience (multi-colour panel preparation antibodies titration cell staining FlowJo analysis)

• Ability to deliver high quality consistent results in a timely fashion with a positive can-do and result oriented attitude

Preferred Qualifications & Skills:

Please note the following skills are not necessary just preferred if you do not have them please still apply:

• Background of immunology

• A track record of scientific publication

• Experience in collaboration with biopharma

• Experience in laboratory automation.

Closing Date for Applications 13th February 2026

Please take a copy of the Job Description as this will not be available post closure of the advert.

When applying for this role please use the cover letter of the online application or your CV to describe how you meet the competencies for this role as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK we have bold ambitions for patients aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines combining our understanding of the immune system with cutting-edge technology to transform peoples fosters a culture ambitious for patients accountable for impact and committed to doing the right thing making sure that we focus our efforts on accelerating significant assets that meet patients needs and have the highest probability of success. Were uniting science technology and talent to get ahead of disease together.

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Why GSK

Uniting science technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade as a successful growing company where people can thrive.

We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale.

People and patients around the world count on the medicines and vaccines we make so were committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients accountable for impact and doing the right thing is the foundation for how together we deliver for patients shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race color religion sex (including pregnancy gender identity and sexual orientation) parental status national origin age disability genetic information (including family medical history) military service or any basis prohibited under federal state or local law.

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