Post Doctoral Fellow- de la Puente Lab

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Job Description

Job description:

Postdoctoral position is available in the laboratory of Prof. Pilar de la Puente Sanford Research Sioux Falls to study dynamics of dysregulation of the extracellular matrix (ECM) composition in ovarian cancer. la Puente labs mission is focused on the engineering of translational and physiologically relevant preclinical cancer models to advance ovarian cancer research. ( The de la Puente Lab develops translational and physiologically relevant preclinical cancer models as tools to recapitulate tumor behavior ex vivo (out of the living) with an emphasis in cellular crosstalk extracellular matrix remodeling and spatial gradients. We focus on elucidating mechanisms driving chemoresistance and immune evasion in ovarian cancer and further developing novel treatment strategies to mitigate their occurrence. Our long-term goal is to accelerate and directly translate our significant insights to aid patients suffering from ovarian cancer.

Requirements:

Interested candidate is expected to have recently obtained a PhD in Biomedical Engineering Biology or similar discipline and be a first author on at least 1-2 publications in Cancer cell-ECM mechanotransduction and/or biomedical engineering applications. The main job duty is to perform research to understand the role of tumor extracellular matrix remodeling in ovarian cancer chemoresistance and to identify novel therapeutic targets by using patient-derived 3D cultures (Funding already secured). The translational research project leverages multi-disciplinary approach in cancer biology bio-orthogonal metabolic labeling biomedical engineering/tissue engineering mechanotransduction signaling OMICs and high-throughput in vitro patient-derived models to probe complex biological processes and to pursue new therapeutic opportunities for cancer. Experience in 3D tissue cultures confocal imaging and/or cancer biology is preferred. Excellent oral and written communication skills in English are required. Our laboratory is an inclusive and supportive environment and we strongly encourage motivated individuals from historically excluded groups in science to apply.

Assists in completion of grant applications and other regulatory documents. Writes technical summaries and co-authors articles for publication. Prepares and makes formal presentations of research results. Typically works under broad direction of principal investigator. High level of knowledge in scientific research processes procedures and objectives. Possesses ability to implement experiments in the subject discipline with the ability to trouble shoot issues. Good knowledge of the principles and techniques of the subject discipline required. Teach principles and techniques of medical and laboratory procedures to junior individuals working in the lab. Possesses ability to run complex pieces of equipment requiring advanced specialized training. Possesses knowledge of modern research methods data collection and analysis. Significant experience in analyzing and evaluating data. General level of knowledge of project management decision-making and analytical skills. Strong verbal written and interpersonal communication skills. Ability to work collaboratively with a research group or team. Sanford Research is a multi-site institution and occasional local travel between sites may be required.

Qualifications

Sanford is an EEO/AA Employer M/F/Disability/Vet.

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