Associate Director, Medicinal Chemistry

Redwood City, CA - USA

Monthly Salary: Not Disclosed

Posted on: Yesterday

Vacancies: 1 Vacancy

Job Summary

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team you will join other outstanding Revolutionariesin a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Revolution Medicines is seeking a scientifically talented individual to join our world-class Discovery Research organization as an Associate Director of Medicinal Chemistry. This position focuses on early hit discovery and offers opportunities to play a critical role across multiple stages of drug discovery including hit-to-lead lead optimization and delivering high-quality anti-cancer drug candidates. This is a managerial role reporting to the Director of Medicinal Chemistry and includes both scientific leadership and people management responsibilities within a highly collaborative cross-functional environment.

Lead and execute medicinal chemistry strategies for early-stage discovery programs including target validation hit finding and hit-to-lead optimization.
Design and drive efficient hypothesis-driven DesignMakeTestAnalyze (DMTA) cycles to deliver differentiated small-molecule leads and development candidates.
Identify key scientific risks define mitigation strategies and provide data-driven recommendations at project decision points.
Collaborate closely with cross-functional partners in Screening Sciences Discovery Biology Computational Chemistry DMPK Pharmacology and CMC to ensure integrated project progression and timely delivery.
Communicate project strategy data and conclusions clearly to cross-functional teams and senior leadership.
Provide scientific oversight and direction for external chemistry CRO activities to ensure quality efficiency and alignment with program objectives.
Contribute to invention disclosures patent filings and external scientific publications.
Champion best practices in medicinal chemistry and continuously improve scientific and operational effectiveness.
Manage coach and mentor medicinal chemists providing technical guidance performance feedback and career development support.
Foster a culture of scientific excellence accountability and collaboration consistent with RevMeds Integrated Discovery Research vision.

Required Skills Experience and Education:

Ph.D. degree in chemistry.
Minimum of 5 years of experience in the pharmaceutical/biotech industry with a track record of scientific innovation in the medicinal chemistry discipline.
Working knowledge of modern medicinal chemistry and drug discovery approaches.
Track record of involvement in identifying a development candidate with a deep understanding of hit generation hit-to-lead structure-based drug design and lead optimization.
Experience managing scientific collaborations and external CRO resources.
Strong problem-solving skills with sound technically driven decision-making
Effective written and verbal communication skills and interpersonal
An innovative team-player and leader with capacity to be effective in a dynamic and fast-paced environment.

Preferred Skills:

Experience in beyond Rule-of-Five (bRo5) small-molecule drug discovery.
Experience in oncology drug discovery research.
Experience in targeting historically undruggable targets through approaches such as covalent inhibitors macrocycles molecular glues and other alternative modalities.
Demonstrated leadership experience including mentoring and developing scientists within multidisciplinary teams. #LI-Hybrid #LI-LN1

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role level and location. Individual base pay salary is determined by multiple factors including job-related skills experience market dynamics and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed which includes competitive cash compensation robust equity awards strong benefits and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race color religion gender sexual orientation gender identity/expression national origin/ancestry age disability marital status medical condition and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect process and use any personal data that you provide to us in accordance with ourCCPA additional information please contact .

Base Pay Salary Range

$186000$233000 USD

Required Experience:

Director