Principal Scientist, Immunology Biomarker Lead, Translational Medicine

Job Description

Translational Biomarkers (TB) develops and validates clinical biomarkers to support decision making across the development lifecycle for all therapeutic areas at our Companys Research laboratories. We are seeking a highly-motivated Principal Scientist to serve as an Immunology Biomarker Lead who will partner across functions to design and deliver biomarker strategies that connect drug mechanism patient biology and clinical endpoints across immune-mediated and inflammatory diseases.

The role requires a scientist who leads through scientific expertise decision-focused logic and collaboration building alignment among teams on biomarker hypotheses plans and readouts tied to development decisions in a fast-moving matrixed environment.

The individual will have the following responsibilities:

• Shape and align biomarker strategies for early and late-stage clinical programs emphasizing clear hypotheses fit-for-purpose readouts and decision-linked plans.

• Lead biomarker sub-teams within cross-functional development program teams and provide functional area point of view in governance interactions.

• Build alignment across stakeholders with diverse technical backgrounds priorities and perspectives to converge on pragmatic biomarker choices and tradeoffs as needed.

• Partner with subject matter experts to translate disease biology and drug mechanism into clinical stage biomarker plans that address key program questions and integrate diverse technical perspectives.

• Facilitate fit-for-purpose selection of innovative biomarker technologies and methodologies (e.g. immune profiling omics digital pathology) grounded in disease pathophysiology and aligned with therapeutic mechanism of action.

• Contribute to analysis planning and interpretation to ensure biomarker conclusions are scientifically rigorous clinically meaningful and clearly communicated both internally and externally.

Position Qualifications:

Education Minimum Requirement:

• PhD (or MD/PhD) in a life sciences discipline (Biochemistry Immunology Molecular Pathology Cell Biology Translational Medicine Pharmacology Genetics/Genomics Bioengineering or STEM related field).

• MS or BS considered with equivalent experience.

Required Experience and Skills:

• PhD (or MD/PhD) 7 years OR MS and 10 years OR BS and 12 years of experience in the biotech or pharmaceutical industry specifically in translational or biomarker sciences.

• Demonstrated ability to lead through influence in highly matrixed environments driving outcomes without formal authority through scientific credibility relationship-building and strategic stakeholder engagement.

• Strong knowledge of immune-mediated and inflammatory disease biology and clinical development spanning at least one of the following areas: gastrointestinal/mucosal inflammation rheumatology dermatology.

• Demonstrated experience applying biomarkers to assess drug activity and patient response to inform therapeutic decision making.

• Excellent analytical problem-solving and communication skills with the ability to synthesize ambiguity into clear options and recommendations as needed.

Preferred Qualifications:

• Experience with fluid- and tissue-linked biomarker readouts and connecting them to clinical endpoints.

• Working knowledge of biomarker platforms and multi-modal data integration (e.g. immunoassays flow/immune profiling NGS omics) with effective partnership across data sciences bioinformatics and biostatistics.

• Experience advancing precision medicine concepts and diagnostic considerations into clinical biomarker plans is advantageous.

• External scientific engagement including KOL collaborations publications presentations and/or scientific consortia participation.

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Effective September 5 2023 employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week Monday - Thursday although the specific days may vary by site or organization with Friday designated as a remote-working day unless business critical tasks require an on-site Hybrid work model does not apply to and daily in-person attendance is required for field-based positions; facility-based manufacturing-based or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.

The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

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Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance

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