Division Director Clinical Pharmacology & Toxicology

Do you envision finding a meaningful role with an inclusive and compassionate team At Childrens Mercy we believe in making a difference in the lives of all children and shining a light of hope to the patients and families we serve. Our employees make the difference which is why we have been recognized by U.S. News & World Report as a top pediatric hospital for eleven consecutive years.

Childrens Mercy is in the heart of Kansas City a metro abounding in cultural experiences vibrant communities and thriving businesses. This is where our patients and families live work and play. This is a community that has embraced our hospital and we strive to say thanks by giving back. As a leader in childrens health we engage in meaningful programs and partnerships throughout the region so that we can improve the lives of children beyond the walls of our hospital.

The Department of Pediatrics at Childrens Mercy seeks a creative and scholarly leader to serve as Division Director of Clinical Pharmacology Toxicology and Therapeutic Innovation. The Division Director will be responsible for leading the research educational and quality missions of Clinical Pharmacology an academic division focused on providing clinical consultation and research programs aimed at making the use of medications in children safer and more effective. Within the division the Section of Medical Toxicology provides consultative services for potential poison exposures including overdoses environmental exposures and envenomations. The Division Director will foster collaborative ties throughout Childrens Mercy bridging the divisions research missions in genomic clinical research and translational interests across the Department of Pediatrics and CMRI.

This is a faculty position offering academic appointments at the University of Missouri Kansas City School of Medicine and the Kansas University School of Medicine rank to be commensurate with experience.

Established in 1996 Clinical Pharmacology has a national and international reputation for impactful translational science and excellence in training. The Division has a strong record for successful extramural funding and an outstanding publication record. Clinical Pharmacology faculty and staff are national leaders in pharmacogenetics institutional leaders in health equity research and outstanding clinicians using pharmacology and toxicology to improve the care of patients. Among the groups in the Division are:

• GOLDILOKs Clinic (GOLDILOKSstands forGenomic- andOntogeny-LinkedDoseIndividualization and cLinicalOptimization forKidS.) is a multidisciplinary clinic with a pediatrician clinical pharmacist and nurse who see patients with a variety of conditions including adverse drug reactions drug-drug interactions and medication nonresponse. Additionally the clinical staff meet weekly with genetics lab experts and a social worker to discuss upcoming patients and formulate a multidisciplinary care plan individualized to each patient. The clinic offers educational opportunities to pharmacy students medical students residents and fellows.

• The Medical Toxicology Consult Team provides consultative services for a variety of environmental exposure overdose and poison issues. A Childrens Mercy Medical Toxicologist is on call 24 hours a day seven days a week. Our toxicologists also provide medical direction for the Kansas Poison Control Center. This service on average has 150-200 beside consults per year. Academically the toxicologists provide lectures to CMH Pediatric Emergency Medicine fellows and residents CMH Pediatric Medicine fellows TMC/University Health Emergency Medicine residents and 5^th/6^th year UMKC medical continuing the collaboration of research Kansas Fights Addiction Grant-Opioid Withdrawal Treatment Clinical Practice Guideline was rewarded.

• Childrens Mercy Hospital (CMH) Pediatric Clinical Pharmacology (T32) training program is the Division of Clinical Pharmacology and Toxicology at CMH one of the largest and most comprehensive Pediatric Clinical Pharmacology programs in North America. Our fellowship training program is accredited by the American Board of Clinical Pharmacology (ABCP) and has formally trained 31 fellows since 1998 (21 pediatricians 6 pharmacists 1 advanced practice nurse 3 PhD scientists).

• The drug biotransformation core serves to characterize drug disposition pathways along with the consequences of drug metabolizing enzyme (DME) polymorphisms in subcellular systems derived from pediatric tissues. A cell culture facility permits fellows and faculty to explore the regulation and expression of DME related proteins. A robust analytical core supports in vitro and in vivo pharmacology- and metabolomics-related research emphasizing the characterization of developmental trajectories of drug disposition and response pathways. Partnerships with University of Kansas Nuclear Magnetic Resonance (NMR) spectroscopy core allow for the characterization of drug metabolites or biomarker development. The Analytical Chemistry Core Director can provide both didactic and hands-on instruction to our trainees on quantitative pharmacology methods.

• We have an internationally recognized pharmacogenetics/genomics (PGx) program defining gene sequence variations related to drug disposition and action. This program also administers the Pharmacogene Variation (PharmVar) Consortium. The Pharmacogene Variation (PharmVar) Consortium is a globally recognized central repository for pharmacogene (PGx) variation. The major focus of PharmVar is to catalogue allelic variation of genes impacting drug metabolism disposition and response and provide a unifying designation system (nomenclature) for the global pharmacogenetic/genomic community.

• A team of dedicated health care providers and researchers in our Clinical Pharmacology Division and Division of Clinical Genetics and Genomics offer an in-house pharmacogenetic test called Kiddose PGx. This test helps clinicians better understand how to dose medications for each specific patient when genetic differences may play a role in their bodys response to pharmaceuticals.

• Quality Improvement projects include Decreasing Turnaround Time of Pharmacogenetic Testing which won a poster award at the UMKC School of Medicine QIPS Day. Currently there is an ongoing project to Decrease Insurance Preauthorization Time for Pharmacogenetic Testing. Within our faculty roster we have someone who is an UMKC School of Medicine QIPS Faculty Scholar.

Through strategic team science collaboration with colleagues locally nationally and internationally Clinical Pharmacology Toxicology and Therapeutic Innovation has leveraged Childrens Mercy strengths in clinical care genomics and clinical pharmacology to improve care enhance research and speed translation of best practice into the community.

The foremost qualities necessary for this position is vision for the field of clinical pharmacology research and patient care. Other desired characteristics include 1) a track record of extramural funding; 2) history of mentorship that includes developing young investigators into independent scientists; 2) interest in academic infrastructure and research finances; 3) successful collaborations with administration hospital medical and research partners; 4) unwavering commitment to the principles of diversity equity and inclusion; and 5) commitment to developing a culture of high team accountability and professionalism.

The individual selected for this position will be a strategic and highly communicative leader with a doctoral degree (MD DO MD/PhD DO/PhD PhD or PharmD). The Division Director of Clinical Pharmacology Toxicology & Therapeutic Innovation reports to the Chair of Pediatrics.

About Childrens Mercy

Childrens Mercy is one of the United Statesleading non-profit independent pediatric health systems offering a comprehensive suite of departments centers and in 1897 Childrens Mercy is dedicated to holistic care impactful research breakthrough innovation and educating the next generation of caregivers. Guided by our mission vision and values our aim is to create a world of wellbeing for allchildren. Childrens Mercy is consistently ranked among the best childrens hospitals in the nation by US News & World Report and we were the first hospitalin Missouri or Kansas to receive Magnet designation for excellence in patient care from the American Nurses Credentialing Center an honor we have received six consecutive times.

Some Childrens Mercy facts and figures:

• 390licensed beds
• Nearly 800 faculty
• Over 50 specialties
• 600000 totalvisits
• 190000 emergency and urgent care visits
• 20000 surgicalcases
• Primary service area includes150 counties in Missouri and Kansas
• Level1 Childrens Surgery Center by the American College of Surgeons
• Only pediatricLevel1 Trauma Center between and Denver
• Comprehensive solid organ transplant center with sustained exceptional outcomes

Education

Education is a core tenet of Childrens Mercy. Childrens Mercy provides education opportunities to nursing students medical students residents and fellows supporting over 1400 learners annually. Childrens Mercy is the pediatric clerkship site for both UMKC and KU medical students and provides elective rotations and sub-internships to students at any accredited allopathic or osteopathic medical school. Childrens Mercy is highly active in Graduate Medical Education with accredited residencies in pediatrics med/peds child neurology pediatric dentistry pediatric optometry and pharmacy. Childrens Mercy offers more than 40 fellowship programs across numerous areas developing the next generation of subspecialists. Certificate and masters programs are also operated in conjunction with its academic partners the University of Kansas (KU) and the University of Missouri Kansas City (UMKC). Finally our robust clinical training resources are augmented by research opportunities for learners at all levels.

Research

Childrens Mercy is dedicated to becoming a leader in pediatric research. A directed strategic planning initiative established the Childrens Mercy Research Institute (CMRI) to focus on research and research infrastructure. Through the generosity of two philanthropic gifts totaling $150 million the hospital constructed a nine story 375000 square foot research facility to provide scientists with state-of-the-art addition these generous gifts help support funding for scientific programs and recruitment. Research conducted today includes basic translational and clinical research in numerous areas including pharmacology cancer cardiology genetic diseases and health outcomes. Areas of research strength include Precision Therapeutics Genomic Medicine Population Health Emerging Pathogens and Innovations in Health Care Delivery. Beyond these areas of emphasis Childrens Mercy and the CMRI also provide encompassing resources for Childrens Mercy faculty to pursue research from developing a research question biostatistical planning grant application and management and coordination of clinical trials.

About Kansas City

Crossing into both Missouri and Kansas the Kansas City Metropolitan Area is an affordable and comfortable place to live and raise a family. The metros anchor city Kansas City Missouri is the largest city in the state and has great museums a busy downtown multiple professional sports franchises an exciting music scene and many charming neighborhoods. Throughout the Metro area you will find highly ranked public schools beautiful parks and other green spaces and lots of amazing people. Kansas City is large enough to provide the amenities of a metropolitan area while small enough to allow for easy commutes assessable amenities and a very high quality of life.

Ideal Qualifications and Experience

• MD DO PhD or PharmD (or combination of degrees) is required
• Current academic rank of Associate Professor or Professor
• A strong record of academic achievement as evidenced by extramural funding in the field of Clinical Pharmacology
• Demonstrated interest in advancing research as it pertains to division activities and interactions with the broader Childrens Mercy community
• A commitment to our true north pillars: quality and safety people patient experience delivery and stewardship
• Fosters and models our values: kindness curiosity inclusion team and integrity
• A deep commitment to fostering and supporting programs that address equity inclusion and diversity
• A track record of partnership with academic medical centers
• Strong interpersonal skills and the ability and commitment to collaborate with leadership at partner institutions

Nominations and Applications (cover letter and curriculum vitae) should be submitted via e-mail to:

All materials will be treated as confidential.

Childrens Mercy is an Equal Opportunity/Affirmative Action Employer. For additional information please visit our website at .

At Childrens Mercy we are committed to ensuring that everyone feels welcomed within our walls. A successful candidate for this position will join us as we strive to create a workplace that reflects the community we serve as well as our core values of kindness curiosity inclusion team and integrity.

Additionally its important to us that we remain transparent with all potential job candidates. Because we value the safety of the patients and families we serve as well as the Childrens Mercy staff we want to let you know that the seasonal influenza vaccine is a condition of employment for all employees in our organization. New employees must be willing to be vaccinated if found non-immune to measles mumps rubella (MMR) and chicken pox (varicella) and/or without evidence of tetanus diphtheria acellular pertussis (Tdap) vaccination since 2005. If you are selected for this position you will be asked to supply your immunization records as proof of vaccination. If you and have any concerns about receiving these vaccines medical and/or religious exemptions can be further discussed with Human Resources.

Childrens Mercy hires individuals based on their job skills expertise and ability to maintain professional relationships with fellow employees patients parents and visitors. A personal interview formal education and training previous work experience references and a criminal background investigation are all factors used to select the best candidates. The hospital does not discriminate against prospective or current employees based on the race color religion sex national origin age disability creed genetic information sexual orientation gender identity or expression ancestry or veteran status. A drug screen will be performed upon hire. Childrens Mercy is smoke and tobacco free.

CM is committed to creating a workforce that supports the diverse backgrounds of our patients and families. We know that our greatest strengths come from the people who make up our team so we hire great people from a wide variety of backgrounds not just because its the right thing to do but because it makes our hospital stronger and our patient care more compassionate.

If you share our values and our enthusiasm for service you will find a recruiting for our team we welcome the unique contributions that you can bring including education ideas culture and beliefs.