Sr Scientist, Analytical Ops

At Gilead were creating a healthier world for all people. For more than 35 years weve tackled diseases such as HIV viral hepatitis COVID-19 and cancer working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the worlds biggest health challenges and our mission requires collaboration determination and a relentless drive to make a difference.

Every member of Gileads team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions and were looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future you are the key driver in evolving our culture and creating an environment where every employee feels included developed and empowered to fulfil their aspirations. Join Gilead and help create possible together.

Job Description

Gilead Sciences Inc. is a research-based biopharmaceutical company founded in 1987. Together we deliver life-saving therapies to patients in need. With the commitment and drive you bring to the workplace every day you will be part of a team that is changing the world and helping millions of people live healthier more fulfilling lives. Our worldwide staff is a close community where you can see the tangible results of your contributions where every individual matters and everyone has a chance to enhance their skills through ongoing development. Our scientific focus has resulted in marketed products that are benefiting hundreds of thousands of people a pipeline of strong late-stage drug candidates and unmatched patient access programs to ensure medications are available to those who could otherwise not afford them. By joining Gilead you will further our mission to address unmet medical needs and improve life by advancing the care of patients with life-threatening diseases.

The successful candidate will possess a detailed understanding of proteins and carbohydrates. The candidate must be highly motivated to contribute to the research and development of biologics targeting unmet medical needs through biochemical characterization and novel method development supporting clinical and commercial programs. Experience in several of the following fields is strongly desired: analytical chemistry biochemistry biological mass spectrometry high performance or ultra-performance liquid chromatography electrophoretic separations enzymology statistics chemical and biophysical structural elucidation and bioinformatics.

*At a future date this position will relocate to the corporate HQ in Foster City CA.

Key Responsibilities:

• Support late-stage assay development by performing mass spectrometry to characterize molecules degradation pathways and define critical quality attributes in a phase-appropriate context.
• Contribute to analytical method development and qualification for protein characterization.
• Develop innovative assays to gain competitive advantages over standard industry practices.
• Support comparability and stability studies using mass spectrometry.
• Operate maintain and troubleshoot Waters Sciex Bruker QTOFs and Thermo Orbitrap mass spectrometers.
• Solve complex problems requiring evaluation of intangible variables using logic ingenuity and creativity.
• Collaborate with junior and senior team members to advance state-of-the-art characterization techniques.
• Represent the Structure Characterization group in cross-functional project teams.
• Participate in technology transfer of assays to QC and external CRO/CMOs.
• Coordinate analysis of in-process and product-related impurities for process comparability studies.
• Conduct scientific research to support drug candidate development and marketed drug research.
• Advise project teams on experiment planning and execution considering economic regulatory and safety factors.
• Present results interpret data and draw conclusions from experimental findings.
• Stay current with scientific literature and apply relevant knowledge to projects.
• Represent the company at national and international conferences.

Basic Qualifications

• BS degree with at least 8 years of industry experience OR MS degree with at least 6 years of industry experience.
• Strong knowledge of mass spectrometry experimental design and assay development.
• Demonstrated ability to lead in a cross-functional environment and mentor junior team members.
• Ability to work independently with minimal supervision.
• Excellent verbal technical writing and interpersonal communication skills.
• Proficient in Microsoft Office applications.

Preferred Qualifications

• PhD in Chemistry or related discipline with at least 2 years of industry experience
• Familiarity with techniques such as:
  • Peptide mapping by LC-MS/MS
  • Intact mass analysis
  • MS/MS for protein and carbohydrate structural elucidation/quantification
  • Kinetic analyses
  • Ultra-performance chromatography
  • Proteolytic/chemical processing
• Knowledge of ICH guidelines and GMP.
• Expertise in mass spectrometry analysis software (Protein Metrics Thermo BioPharma Finder Skyline).
• Experience with data analysis and visualization tools (Python R JMP Spotfire).
• Strong organizational and planning skills.
• Ability to work effectively in a matrixed environment and communicate assay results and issues clearly.

For additional benefits information visit:

Eligible employees may participate in benefit plans subject to the terms and conditions of the applicable plans.

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Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment and is dedicated to fostering an inclusive work environment comprised of diverse perspectives backgrounds and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race color religion national origin sex age sexual orientation physical or mental disabilitygenetic information or characteristic gender identity and expression veteran status or other non-job related characteristics or other prohibited grounds specified in applicable federal state and local order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973 the Vietnam Era Veterans Readjustment Act of 1974 and Title I of the Americans with Disabilities Act of 1990 applicants who require accommodation in the job application process may contact for assistance.

For more information about equal employment opportunity protections please view theKnow Your Rights poster.

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Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

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