Biomedical Modeler & Pharmacometrician - Division of Pharmaceutical Sciences (Bulitta Lab)

The Biomedical Modeler & Pharmacometrician performs advanced pharmacometric modeling and/or statistical analysis to support laboratory and/or clinical research projects. Performs tasks related to the project independently and in addition to widely accepted approaches to data analysis may utilize novel approaches. Assists with performing manuscript preparation to disseminate results of the modeling in peer-reviewed publications.

The Bulitta Lab in the Department of Pharmacy and Pharmaceutical Sciences Division of Pharmaceutical Sciences at St. Jude Childrens Research Hospital is seeking a Biomedical Modeler & Pharmacometrician. Previous experience working with Dr. Bulitta is preferred.

Job Responsibilities:

• Provide pharmacometric expertise to researchers as designated by collaboration areas in all aspects of conducting pharmacometric and/or statistical analyses for basic translational and/or clinical studies. Assists with acquiring or acquires the data for modeling and verifies the data prior to modeling.
• Understand integrate and use widely accepted as well as novel approaches to pharmacometric modeling and statistical analysis (e.g. R Matlab).
• Utilize routine pharmacometric software (e.g. ADAPT NONMEM Monolix WinNonlin SimCYP PK Sim MOBI GastroPlus) to conduct noncompartmental as well as compartmental analyses.
• Introduce novel and state-of-the-art pharmacometric modeling techniques as project warrants.
• Perform and document mathematical modeling and statistical analysis of research data and prepare the results in an accepted format.
• Participate in the development of software interfaces for clinical programs necessary for pharmacokinetic and drug dosage adjustment for clinical protocols.
• Design coordinate supervise and implement quality control procedures for both clinical and preclinical research data. Develop appropriate methods to ensure the validity of pharmacometric research data. Works with Lab database to ensure validity of pharmacometric research data.
• Assist in the preparation of pharmacometric results for meeting abstracts posters and peer-reviewed manuscripts. May serve as a co-author or in select cases as a primary author on biomedical modeling
• related publications.
• Provides education and training in pharmacometric techniques to individuals as assigned by the supervisor.
• Maintains regular and predictable attendance.
• Performs other related duties as assigned in order to meet the goals and objectives of the department and institution.

Minimum Education and/or Training:

• Bachelors degree in mathematics engineering or computer science with advanced training in pharmacometrics and/or quantitative systems biology modeling is required.
• Masters degree or PhD in mathematics biomedical engineering or related field with advanced training in pharmacometrics and/or quantitative systems biology modeling is preferred.

Minimum Experience:

• Four (4) years of relevant experience in pharmacometrics biostatistics and/or a relevant research field.
• With a PhD three (3) years of relevant experience in a pharmacometric or biostatistics and/or a relevant research field is required.
• Experience in standard pharmacometric and statistical methods software and study design is preferred.

Special Skills Knowledge and Abilities:

• Comprehensive knowledge of pharmacokinetic/pharmacodynamic modeling theory including model building parameter estimation methods for individual studies (maximum likelihood and Bayesian methods) and population studies (nonlinear mixed-effects modeling methods) and hypothesis testing
• Comprehensive knowledge of the concepts underlying physiological modeling and systems modeling theory with specific knowledge of differential equations applications
• Ability to perform modeling and simulation studies
• Ability to design and perform quality control analysis
• Working knowledge of PK/PD and modeling software such as ADAPT 5 NONMEM Matlab R S-ADAPT Monolix and FORTRAN
• Working knowledge of computer hardware including the Windows and LINUX operating systems
• Proven ability to read pharmacokinetic and mathematical literature and implement new methods into model development
• Basic knowledge of medical scientific and statistical terminology
• Leadership ability to provide guidance and direction to junior level employees
• Ability to express ideas and views effectively when speaking to groups and individuals. Ability to communicate with both faculty and staff
• Ability and temperament to adapt to changing conditions and various job details
• Ability to translate technical terminology into terms understandable to faculty and staff
• Ability to effectively present oral and written reports
• Ability to read and interpret technical literature about changes in technology software and equipment
• Ability or temperament to meet the public and other hospital staff in a tactful pleasant and helpful manner

Compensation

In recognition of certain U.S. state and municipal pay transparency laws St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets experience and training licensure and certifications and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $94640 - $169520 per year for the role of Biomedical Modeler & Pharmacometrician - Division of Pharmaceutical Sciences (Bulitta Lab).

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