General Manager, Rare Diseases
General Manager, Rare Diseases
Employer Active
Job Alert
You will be updated with latest job alerts via email
Share
Job Alert
You will be updated with latest job alerts via email
Job Description
The Role:
As the General Manager for Rare Diseases you will report to the Chief Marketing Officer and have end-to-end accountability for the Rare Disease Business Unit (BU) including mRNA-3927 for Propionic Acidemia (PA) mRNA-3705 for Methylmalonic Acidemia (MMA) and a pipeline of pre-clinical candidates. This is an enterprise-level leadership role with cross-functional accountability.
In addition to managing the P&L setting strategy and leading commercialization efforts you will integrate activities across critical functions such as Manufacturing Research and Clinical Development. While you will have dotted-line functional reports from these areas you will also maintain dual accountability to relevant enterprise leaders. This includes ensuring that strategic planning execution and communication align with the broader corporate goals and stakeholder expectations.
You will also serve as the Rare Disease Franchise Lead managing the marketing team directly while also acting as a key integrator across internal teams to drive prioritization resourcing and global-to-local readiness for successful asset launches and long-term portfolio growth.
Heres What Youll Do:
Lead Modernas Rare Disease Franchise with full strategic operational and financial accountability
Manage the Business Unit P&L
Own the integrated franchise strategy including pipeline prioritization lifecycle planning and long-range forecasting
Develop compelling business cases and value narratives that shape investment and development decisions
Represent Rare Disease in governance forums and drive cross-functional priority-setting aligned with company strategy
Orchestrate execution across Marketing R&D Medical Access CMC and Supply to deliver launches on time and within budget
Shape the go-to-market model brand strategy and external positioning to ensure global readiness and local adaptability
Partner with country and regional teams to drive alignment insight-sharing and sustained execution across markets
Build and scale commercial infrastructure and capabilities to support asset launches and portfolio expansion
Identify and develop long-term opportunity spaces and commercial innovation within the rare disease landscape
Lead structured planning forecasting budget management and KPI tracking across the franchise
Influence enterprise-level portfolio prioritization and long-term growth strategy through active participation in global forums
Heres What Youll Need (Minimum Qualifications):
Bachelors degree required
15 years of progressive experience with significant commercial leadership exposure
Proven track record in end-to-end portfolio leadership including launch execution and lifecycle management
Direct U.S. launch experience in rare or specialty disease areas
Experience leading high-performing teams and cross-functional collaborations
Heres What Youll Bring to the Table (Preferred Qualifications):
Full P&L ownership and accountability for the BU
Experience building and scaling commercial infrastructure in emerging or fast-growth therapeutic areas
Depth in rare or ultra-rare diseases with working knowledge of clinical and regulatory pathways.
Strong understanding of global healthcare systems access models and payer engagement
Demonstrated success building and scaling teams in ambiguous or early-growth environments
Proven ability to influence across R&D Medical Access and G&A functions
Strategic thinker with high learning agility systems orientation and disciplined operational follow-through
Executive presence with clear communication and alignment-building skills across senior leadership.
At Moderna we believe that when you feel your best you can do your best work. Thats why our US benefits and global well-being resources are designed to support youat work at home and everywhere in between.
- Best-in-class healthcare coverage plus a suite of voluntary benefit programs to support your unique needs
- A holistic approach to well-being with access to fitness mindfulness and mental health support
- Lifestyle Spending Accounts to personalize your well-being journey
- Family planning and adoption benefits
- Generous paid time off including vacation volunteer days sabbatical global recharge days and a discretionary year-end shutdown
- Savings and investment opportunities
- Location-specific perks and extras
About Moderna
Since our founding in 2010 we have aspired to build the leading mRNA technology platform the infrastructure to reimagine how medicines are created and delivered and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.
By living our mission values and mindsets every day our people are the driving force behind our scientific progress and our culture. Together we are creating a culture of belonging and building an organization that cares deeply for our patients our employees the environment and our communities.
We are proud to have been recognized as a Science Magazine Top Biopharma Employer a Fast Company Best Workplace for Innovators and a Great Place to Work in the U.S.
If you want to make a difference and join a team that is changing the future of medicine we invite you to visit to learn more about our current opportunities.
Our Working Model
As we build our company we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation teamwork and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn contribute and make a meaningful impact.
Moderna is a smoke-free alcohol-free and drug-free work environment.
Equal Opportunities
Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry or citizenship ethnicity disability military or protected veteran status genetic information sexual orientation marital or familial status or any other personal characteristic protected under applicable is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day please apply!
Moderna is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories consistent with legal requirements.
Accommodations
Were focused on attracting retaining developing and advancing our employees. By cultivating a workplace that values diverse experiences backgrounds and ideas we create an environment where every employee can contribute their best.
Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at .
#LI-AG2-
Required Experience:
Director
Employment Type
Full-Time
