Director, Project Toxicologist, Immune Oncology safety
Director, Project Toxicologist, Immune Oncology safety
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Job Description
Title: Director Project Toxicologist Immune Oncology safety
Location: Cambridge- UK Gaithersburg - USA
Salary: Competitive
At AstraZeneca it is our bold ambition to eliminate cancer as a cause of death. This is underpinned by our rich pipeline aimed to deliver innovative treatment options for Oncology patients.
We are looking for a motivated and passionate individual to join us as an Director Project Toxicologist Immune Oncology Safety with a focus on delivery of transformative immunotherapies to advance our portfolio of innovative anti-cancer medicines in Oncology R&D You will provide non-clinical safety expertise for our diverse Oncology portfolio with particular focus on T cell engagers (TCE) and other Immuno-Oncology (IO) therapeutics. You will play an integral role in driving progression and acceleration of drug projects through discovery and development by designing innovative regulatory toxicology strategies to address drug target- and modality-related risks.
The position can be based at one of our vibrant strategic R&D sites in Gaithersburg (MD) or Cambridge (the UK).
Within AstraZeneca we place a strong emphasis on talent development. You will be able to develop your knowledge and skills by working together with experts and leaders in Immunology R&D safety science pharmacology toxicology drug discovery and development imaging pathology and translational science.
What you will do
As an Associate Director/Director Project Toxicologist in Immune Oncology Safety at AstraZeneca your main accountabilities will be:
As a core member of multi-disciplinary oncology drug development teams you will design deliver and interpret innovative toxicology strategies to predict assess and mitigate target- and modality related safety risks.
Develop and implement innovative solutions to combine regulatory toxicology with ground-breaking science and technologies to progress novel drug candidates to the clinic and through development to the market in line with business needs.
To influence project strategy and decision making you will communicate clear positions on integrated risk assessments in various formats including informing internal decision-making governance bodies and interacting with external health authorities.
Delivering quality nonclinical summaries and other high-level regulatory documents for internal decision bodies and external health authorities.
Maintain expertise in regulatory requirements and preclinical safety approaches applied to Drug Candidates and awareness of industry trends.
Additional responsibilities include providing experienced nonclinical evaluation of in-licensing and out-licensing opportunities and to provide mentorship and guidance to emerging toxicologists with respect to the regulatory environment and support their career growth and development in Immune oncology department.
Requirements for this role
DABT or PhD in toxicology immunology or immunopharmacology with several years of experience in the pharmaceutical or biotechnology industry working as a non-clinical safety lead supporting immune-Oncology programs with planning execution interpretation and communication of regulatory toxicology data.
A proven understanding of drug development and a track record of delivering multiple toxicology programs to IND and through clinical development.
High level of knowledge and expertise in designing toxicology strategies and delivering in vitro/in vivo and risk assessment of immune related risks / adverse events driven by mechanism and/or TCE.
Expertise in immunology or oncology including T-cell biology.
Ability to solve problems in a goal-focused fashion with willingness to challenge conventional thinking and capacity to coordinate tasks across multiple projects.
Excellent verbal and written communication- interpersonal- and influencing skills. Adopting an inclusive and collegiate working style and a desire to drive own- and support others development.
Desirable in the role
Experience with TCE and other large molecules will be desirable.
In addition to possessing scientific competence we value individuals who can contribute to our inclusive positive and collaborative working environment.
DABT is considered an advantage.
When we put unexpected teams in the same room we fuel ambitious thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
Join the team unlocking the power of what science can do. We are working towards treating preventing modifying and even curing some of the worlds most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference by fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. Our combination of curiosity and courage drives us to explore new possibilities without fear of failure. We celebrate our successes and learn from our failures along the way. Our inclusive environment allows us to work seamlessly as one team using diverse global knowledge to create the greatest impact on disease.
If your passion is science and you want to be part of a team that makes a bigger impact on patients lives then theres no better place to be. Apply now!
what is next
Are you ready to make a difference Apply today and join us in our mission to improve global public health!
We welcome your applications not later than 8th June 2025.
Where can I find out more
Follow AstraZeneca on LinkedIn AstraZeneca on Facebook AstraZeneca on Instagram you ready to make a difference Apply today and join us in our mission to improve global public health!
Date Posted
23-May-2025Closing Date
08-Jun-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Director
Employment Type
Full-Time
