Thesis work, 45-60 credits - Structure elucidation of drug metabolites with mass spectrometry: Evaluation of alternative fragmentations techniques to collision-induced dissociation
Thesis work, 45-60 credits - Structure elucidation of drug metabolites with mass spectrometry: Evaluation of alternative fragmentations techniques to collision-induced dissociation
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Job Description
Are you looking for an impactful thesis project that bridges cuttingedge technology with realworld pharmaceutical challenges At AstraZeneca we offer a unique opportunity within our Early CVRM research area where your work will contribute directly to the development of nextgeneration therapeutics. Join us to explore how advanced mass spectrometry techniques can revolutionize the structural elucidation of drug metabolites shaping the future of drug discovery.
About AstraZeneca:
AstraZeneca is a global scienceled patientcentered biopharmaceutical company focusing on discovering developing and commercializing prescription medicines for some of the worlds most serious diseases. But were more than a global leading pharmaceutical company. At AstraZeneca were dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit.
About Early CVRM:
Join Early CVRM one of AstraZenecas therapeutic research areas focusing on delivering candidate drugs into latestage clinical development. Our global function perform research in Gaithersburg US Cambridge UK and Gothenburg Sweden. The opportunity is within the DMPK Drug Design and Biotransformation team part of the DMPK department based at AstraZenecas R&D center in Gothenburg Sweden. At DMPK we collaborate across functions to support CVRM projects throughout the value chainfrom target selection to market launch and lifecycle management.
About the Opportunity:
As a Thesis Worker at AstraZeneca youll find an environment thats full of unique opportunities and you will be able to build and increase your network. Here youll have the opportunity to learn more within your areas of interest and develop a broad skillset on how to share the scientific work with a broader community both in writing and oral presentation.
Thesis work description:
You will have the opportunity to explore how advanced LCHRMS instruments equipped with MSn capabilities and complementary fragmentation techniques enhance the structural elucidation of drug metabolites. Identifying metabolic hotspots of molecules is key data to generate to be able to develop drug candidates with optimal ADME properties.
The project emphasizes phase II metabolites (glucuronide and glutathione conjugates) and phase I metabolites (primarily oxidations) of various drug modalities such as PROTACs and peptides. You will learn how to use the latest mass spectrometry innovations including electron activated dissociation (EAD) and ultraviolet photodissociation (UVPD) which provide additional MS/MS fragments for enhanced structural analysis.
Research Methods/Techniques:
Youll work with stateoftheart MS instruments pivotal for metabolite identification and structural elucidation within DMPK including:
- Synapt XS QTOF(Waters)
- Xevo G3 QTOF(Waters)
- Orbitrap Exploris(Thermo Fisher Scientific)
Evaluate the potential of advanced instruments for offering richer structural insights:
- Orbitrap Eclipse Tribrid with UVPD(Thermo Fisher Scientific)
- ZenoToF with EAD(Sciex)
- TIMSTOF Pro(Bruker)
Structure:
- Credits: 4560hp
- Start date: September 2025
Essential Requirements:
- Ongoing Masters studies in relevant discipline such as analytical medicinal or organic chemistry.
- Bachelors degree in chemistry.
- Basic knowledge of mass spectrometry and liquid chromatography.
- Basic knowledge of organic chemistry.
Desirable Requirements:
- Handson experience from working with mass spectrometry and liquid chromatography.
- Familiar with common biotransformation pathways including understanding of the chemical mechanisms behind metabolite formation.
So whats next
Apply today and take the chance to be part of making a difference making connections and gaining the tools and experience to open doors and fulfil your potential. We cant wait to hear from you!
We welcome your application as soon as possible but ahead of the scheduled closing date 1st of June 2025. In the event that we identify suitable candidates ahead of the scheduled closing date we reserve the right to withdraw the vacancy earlier than published.
Date Posted
07maj2025Closing Date
01juni2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Employment Type
Full-Time
