Division Director - Molecular Oncology & Cellular Therapeutics

Do you envision finding a meaningful role with an inclusive and compassionate team At Childrens Mercy we believe in making a difference in the lives of all children and shining a light of hope to the patients and families we serve. Our employees make the difference which is why we have been recognized by U.S. News & World Report as a top pediatric hospital for eleven consecutive years.

Childrens Mercy is in the heart of Kansas City a metro abounding in cultural experiences vibrant communities and thriving businesses. This is where our patients and families live work and play. This is a community that has embraced our hospital and we strive to say thanks by giving back. As a leader in childrens health we engage in meaningful programs and partnerships throughout the region so that we can improve the lives of children beyond the walls of our hospital.

The Department of Pediatrics at Childrens Mercy (CM) seeks to recruit a creative and scholarly leader to serve as the founding Division Director of our newly established Division of Molecular Oncology & Cellular Therapeutics (MOCT). In close partnership with the Division of Clinical Hematology Oncology and Bone Marrow Transplant (CHOT) MOCT is the academic home for discovery and translational science in the field of hematology/oncology/transplant. The Division Director will be an influential leader who will expand our current laboratorybased research programs and collaborate with faculty members in CHOT to develop new diagnostic and treatment options for pediatric and young adult hematology and oncology patients.

There are currently five principal investigators in MOCT. Funded research includes tumor suppressor pathways glioblastoma diffuse midline glioma infant and other highrisk leukemias leukemia stem cells immunogenic cell death and mitigation of acute and delayed radiation exposure. In addition to augmenting existing research programs a major area of emphasis for the Division Director will be to recruit experienced scientists whose expertise is additive to the entire division and who have a passion for mentoring the next generation of scientists. Childrens Mercy is fortunate to have five available endowed chairs for established scientists whose work is directly relevant to immunotherapy and pediatric malignancies. It is anticipated that the Division Director of MOCT will be appointed to one of these Chairs with the remaining to be used for strategic recruitments.

In addition to CHOT the Division Director will collaborate internally with the Genomic Medicine Center (GMC) and the Genomics Laboratory (Department of Pathology and Laboratory Medicine DPLM) both of which provide advanced cancer genomic sequencing for clinical and research applications. Routine management of all newly diagnosed patients with cancer includes clinical tumor and deep exome germline DNA sequencing using stateoftheart shortread sequencing on the Illumina NovaSeqX platformed in the GMC. The GMC also performs clinical and research molecular characterization of tumor and germline specimens including advanced sequencing technologies such as CLIA and CAPcompliant longread read 5base sequencing (HiFiGS). Furthermore functional characterization of cells and tissues is facilitated by research platforms including singlecell sequencing chromatin and RNAseq. In addition the GMC has a research platform for patientderived organoids. The DPLM provides a full clinical molecular testing suite including cytogenetics pharmacogenetics clinical microarray and optical mapping.

Externally the Division Director will facilitate connections between the Childrens Mercy Research Institute (CMRI) and regional research institutions to collaborate on innovative discovery and translational research. CM is the pediatric partner in the NCIdesignated Kansas University Comprehensive Cancer Center (KUCCC) and has active research collaborations with both the KUCCC and the Stowers Institute for Medical Research.

To achieve the vision of a nationalrecognized research program approximately 7000 square feet of contiguous space is available for programmatic expansion in the CMRI including wet bench laboratory space adjacent faculty offices graduate student and postdoctoral fellow cubicles and shared equipment bays and rooms. Immunotherapeutics and cellular therapy are also significant opportunities for research and programmatic development. Our vision to lead in the field influenced the construction of a 3000 square feet GMP facility adjacent to the laboratory space in the CMRI building. We aim to expand discoveries from immunotherapeutics research towards improved cancer treatments and refined management of both solid organ transplantation and diseases of immunologic origin.

The foremost qualities necessary for this position are a compelling vision for discovery and translational research in hematology oncology bone marrow transplant and cellular therapy (H/O/B/CT). The successful candidate will have a strong track record of academic achievement evidenced by sustained extramural funding and a desire to build a division that will be recognized as a national leader. Other desired characteristics include successful associations with NCI Comprehensive Cancer Centers and a commitment to advancing a culture of high accountability and collaboration. The individual selected for this position will be a strategic and highly communicative leader who holds PhD MD/PhD or MD credentials.

About the Clinical Program. CHOT is divided into 3 sections Hematology Oncology and BMT (H/O/B). CHOT has a longstanding clinical fellowship in H/O/B an advanced fellowship in pediatric coagulation and an advanced research fellowship for trainees committed to a researchintensive career path.

• The Hematology Section has active programs in coagulation sickle cell and general hematology. The Kansas City Regional Hemophilia Treatment Center is among the 5 largest in the country and is a 340B program. The Comprehensive Sickle Cell Program cares for over 300 children and our hematologists oversee the Anticoagulation Management Team and the Coagulation Consult Service staff the Vascular Anomalies Specialty Clinic and codirect the Pediatric Stroke team.

• The Oncology Section has programs focused on specific cancers patient populations & diagnostics and therapeutics. Faculty (MD/DO/PhD) within and outside the Division have a growing presence in cancer research with current focus and grant support in cancer genomics cancer biology experimental therapeutics immunotherapeutics and the impact of ethnic diversity on treatment outcomes. CM is an active COG institution and a member of the COG Pediatric Early PhaseClinical Trial Network (PEPCTN).

• The Blood & Marrow Transplantation/Cellular Therapy Section is both FACT and COGaccredited and we are a regional referral center for BMT of offtrial patients. The program shares a stem cell processing lab with the KUCCC adult BMT program one of the largest in the country. The lab is capable in all stem cell source transplants including related unrelated matched mismatched Tcell depleted haploidentical bone marrow peripheral blood and umbilical cord blood. Building on the early cellular therapy discovery efforts at CM the program can perform complicated graft manipulation for either clinical or research endeavors.

• Further details for all aspects of CHOT may be found on the CMH H/O/BMT webpages which includes over 10 years of Cancer Center Annual reports: Childrens Mercy

  Childrens Mercy is a nationally recognized freestanding childrens hospital founded in 1897 to provide care for poor and ill children of Kansas City. As a freestanding independent childrens hospital CM provides comprehensive pediatric care across the spectrum of primary to quaternary care delivered by 750 doctors in more than 40 subspecialties. Our primary service area encompasses 150 counties in Missouri and Kansas. In 2023 CM conducted nearly 600000 total visits including 55000 telemedicine visits almost 204000 emergency and urgent care visits and 20000 surgical cases. CM is one of only ten centers in the nation verified as a Level 1 Childrens Surgery Center by the American College of Surgeons and the only pediatric Level I Trauma Center in the region. CM has been ranked consistently by U.S. News & World Report in the top 50 of all ten assessed pediatric subspecialties. We enthusiastically complement our nationallyranked subspecialty care with robust community support programs that keep kids safe and healthy.

  Education

  CM is the pediatric clerkship site for both UMKC and KU medical students. Graduate medical education supports over 1400 trainees annually with accredited residencies in pediatrics med/peds child neurology pediatric dentistry pediatric optometry and pharmacy. We have over 40 fellowship programs provide training for psychology interns and postdoctoral fellows and have postdoctoral PhD scientists in clinical and laboratorybased research programs.

  Research

  Childrens Mercy is dedicated to improving the health and wellbeing of children through engagement in worldclass collaborative translation research. Through the generosity of two substantial philanthropic gifts in 2020 CM opened a nine story 375000 square foot facility providing scientists access to stateoftheart technology with ample dry and wet lab spaces. These generous gifts and many others support enhancement of scientific programs and targeted recruitment. Research conducted today includes basic translational and clinical research across many pediatric subspecialties. Areas of strength include Precision Therapeutics Genomic Medicine Population Health and Emerging Infections. CM holds a T32 training grant in Pediatric Clinical Pharmacology and is an impactful member of the Frontiers Clinical and Translational Science Institute (CTSI) at the University of Kansas. This regional CTSI program comprises four universities (including three medical schools) and three health systems on both sides of the MissouriKansas state line.

  About Kansas City:

  The Kansas City Metropolitan Area is an affordable and comfortable place to live and raise a family. The metros anchor city Kansas City Missouri is the largest city in Missouri and has many great museums a busy downtown multiple professional sports franchises an exciting music scene and many charming neighborhoods. The metro area includes four of the seven largest cities in Kansas including Kansas City (Kansas) Overland Park and Olathe. Kansas City is large enough to provide the features of a metropolitan area but still allows for easy commutes assessable amenities and a very high quality of life with highly ranked public schools great parks and other green spaces and lots of amazing people.

  Ideal Qualifications and Experience

  • PhD MD/PhD or MD/DO credential
  • Strong record of academic achievement and success in obtaining extramural support for research
  • Robust national and international research network
  • Demonstrated commitment to developing the next generation of pediatric and young adult H/O/B/CT researchers
  • A commitment to the CM True North pillars: quality and safety people patient experience & family delivery and stewardship
  • Fosters and models the CM values: kindness curiosity inclusion team and integrity
  • A history of success in partnering with clinicians to advance the research mission
  • A deep dedication to fostering and supporting programs that address equity inclusion and diversity
  • Experience in partnering with academic medical centers
  • Strong interpersonal skills and enthusiasm to pursue productive collaborations within CM and our partner institutions

  This is a nonclinical faculty position offering an academic appointment at the University of Missouri Kansas City School of Medicine rank to be commensurate with experience. CM is an Equal Opportunity Employer. The MOCT Division Director reports to the Chair of Pediatrics. We are committed to increasing the diversity of our faculty and staff and fostering their success when hired. Members of underrepresented groups are welcome and strongly encouraged to apply. For additional information please visit our website at

  Nominations and applications (cover letter and curriculum vitae) should be submitted via email to the Search Committee Chair:

  Dr. Tomi Pastinen ()

  CC to

  All materials will be treated as confidential.

  At Childrens Mercy we are committed to ensuring that everyone feels welcomed within our walls. A successful candidate for this position will join us as we strive to create a workplace that reflects the community we serve as well as our core values of kindness curiosity inclusion team and integrity.

  Additionally its important to us that we remain transparent with all potential job candidates. Because we value the safety of the patients and families we serve as well as the Childrens Mercy staff we want to let you know that the seasonal influenza vaccine is a condition of employment for all employees in our organization. New employees must be willing to be vaccinated if found nonimmune to measles mumps rubella (MMR) and chicken pox (varicella) and/or without evidence of tetanus diphtheria acellular pertussis (Tdap) vaccination since 2005. If you are selected for this position you will be asked to supply your immunization records as proof of vaccination. If you and have any concerns about receiving these vaccines medical and/or religious exemptions can be further discussed with Human Resources.

Childrens Mercy hires individuals based on their job skills expertise and ability to maintain professional relationships with fellow employees patients parents and visitors. A personal interview formal education and training previous work experience references and a criminal background investigation all are factors used to select the best candidates. The hospital does not discriminate against prospective or current employees based on the race color religion sex national origin age disability creed genetic information sexual orientation gender identity or expression ancestry or veteran status. A drug screen will be performed upon hire. Childrens Mercy is smoke and tobacco free.

CM is committed to creating a diverse and inclusive workforce. Our patients and families come from all walks of life and so do we. We know that our greatest strengths come from the people who make up our team so we hire great people from a wide variety of backgrounds not just because its the right thing to do but because it makes our hospital stronger and our patient care more compassionate. If you share our values and our enthusiasm for service you will find a home at CM. In recruiting for our team we welcome the unique contributions that you can bring including education ideas culture ethnicity race sex sexual orientation gender identity and expression national origin age languages spoken veteran status color religion disability and beliefs.