Principal Research Scientist I, Analytical Chemistry
Principal Research Scientist I, Analytical Chemistry
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1 Vacancy
Job Description
The Analytical Research & Development team is seeking a talented highly motivated candidate with experience in the characterization of peptide and oligonucleotide biomolecules. The successful candidate will be responsible for designing developing and implementing analytical methods for the characterization of peptides/oligonucleotides using advanced analytical techniques with an emphasis on mass spectrometrybased methods. We are looking for diverse candidates with strong scientific and leadership experience to join the AbbVie Analytical R&D team and can offer exciting and rewarding career opportunities for these candidates. The ideal candidate will have CMC expertise in analytical development for biomolecule therapeutics. The candidate will be responsible for assisting with the development and execution of analytical methods to support CMC and will participate in phaseappropriate characterization of material and products at all stages of the development process as well as monitoring completion of tasks and projects.
Responsibilities:
- Lead development and implementation of advanced analytical characterization methods to support complex peptide and oligonucleotide development programs.
- Utilize cuttingedge structure elucidation techniques (e.g. highresolution tandem mass spectrometry) to characterize a wide range of modalities across AbbVies pipeline including oligonucleotide peptide and small molecule APIs starting materials intermediates and impurities.
- Be responsible for leading the structure elucidation aspects of a project while collaborating with crossfunctional project teams to advance programs through the development pipeline.
- Advance scientific expertise within function. Proactively advise and share knowledge and expert opinions with subordinates peers and senior management. Mentor and train colleagues and assesses current and emerging business challenges enabling functional goal achievement.
- Ensure quality and effectiveness of key results of major project plans through sound design early risk assessments and implementation of fallback strategies.
- Source and identify emerging scientific trends in the field of molecular characterization of therapeutics from internal and external sources and assess relevance. Integrate trends into functional shortterm objectives. Advance technology and direction within area of discipline.
- Apply imagination and innovation by creating inventing and implementing new or better approaches alternatives and breakthrough ideas.
- Make significant contributions to project team and deliver results in a teamoriented setting and will work across scientific disciplines to drive programs through critical milestones.
- Generate new scientific proposals and lead those efforts. Anticipate and critically evaluate scientific or regulatory advances and respond with appropriate new strategies.
Qualifications :
- PhD (with 6 years experience) in scientific discipline (e.g. Analytical Chemistry Biochemistry or related field) with previous laboratory experience.
- Deep understanding of peptide and/or oligonucleotide characterization including higher order structure chiral identification and comparability assessments by mass spectrometry and other biophysical techniques (e.g. optical spectroscopy structure and binding).
- Experience in biomolecule analysis and interpretation by NMR spectroscopy a plus.
- Practical experience and strong knowledge of LC separations (e.g. IPRP LC SEC) capillary electrophoresis and other separation techniques as applied to peptide/oligonucleotide analysis.
- Must possess a solid understanding of peptide/oligonucleotide chemistry and biochemistry particularly as related to drug development process and formulation.
- Experiences with the development of peptides and traditional small molecule modalities are plus.
- Proven ability to innovate with a history of new or improved product release.
- Highquality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our shortterm incentive programs.
This job is eligible to participate in our longterm incentive programs
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
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No
Employment Type :
Fulltime
Employment Type
Full-time
