Postdoctoral Fellow
Postdoctoral Fellow
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1 Vacancy
Job Description
We are seeking a highly motivated postdoctoral candidate with a strong interest inthe mechanisms of synaptic transmission neuronal membrane trafficking or neurodevelopmental disorders.
At the heart of brain function are neuronal synapses. Upon stimulation synapses release neurotransmitters via vesicle exocytosis. Synaptic vesicles are then regenerated through membrane retrieval from the plasma membrane. This process known as synaptic vesicle recycling occurs on the millisecond timescale and can happen approximately 10 to 1000 times per second. For the coordinated signaling across the neuronal network thousands of synapses must synchronously perform vesicle recycling with extremely high temporal precisionan essential requirement for cognition and memory formation. In addition other organellesincluding degradative endosomes lysosomes mitochondria and the cytoskeletonwork in concert with synaptic vesicle recycling to support the complex and heterogeneous nature of neuronal transmission.
How do neurons orchestrate the synchronous activity of hundreds to thousands of distinct organelles with such high temporal resolution How does disruption of this coordination contribute to neurodevelopmental disorders Despite their physiological significance these questions remain difficult to address due to: 1 the spatial coexistence of diverse organelles within the diffractionlimited synaptic compartment; 2 the ultrafast dynamics of membrane trafficking which are difficult to capture using conventional electron microscopy; and 3 the inherent heterogeneity in organelle shape and molecular composition across thousands of synapses which complicates quantitative analysis.
To overcome these technical challenges we have developed experimental paradigms that combine cryovitrified timeresolved electron microscopy and superresolution imaging. This approach enables visualization of membrane dynamics at millisecond resolution and protein localization with 40 nm spatial precision. Furthermore we employ artificial intelligencebased analysis pipelines to dissect the heterogeneous organization of membranes and proteins across largescale brain regions.
Please refer to our website Yuuta Imoto Lab St. Jude Research for further information.
The ideal candidate will be selfmotivated and have strong experience inelectron microscopy superresolution imaging and analyses of cell culture and animal send a summary of previous research curriculum vitae and contact information for references to
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Employment Type
Full-Time
