Experienced and results-driven professional with a robust background in the design, multistep organic synthesis, purification, and characterization of small molecules aimed at potential drug candidates. Proficient in tro…
Experienced and results-driven professional with a robust background in the design, multistep organic synthesis, purification, and characterization of small molecules aimed at potential drug candidates. Proficient in troubleshooting reactions, route optimization, and the work-up and purification of products at milligram to kilogram scales. Demonstrated expertise in utilizing modern small molecule purification techniques and methods with Biotage and/or silica gel pad. Skilled in employing advanced analytical methods such as HPLC, LCMS, and NMR for the identification and characterization of small molecules. Proven track record in designing and optimizing small molecule drug candidates, including biochemical and cell activity, in vitro and in vivo ADME/DMPK, in vivo efficacy, and safety. Capable of analyzing and interpreting SAR data and adept at preparing and presenting comprehensive project summaries. Possesses excellent oral and written communication skills, along with strong interpersonal abilities.
As the author of numerous publications on organic synthesis, molecular recognition, lead optimization of new drugs, and scale-up and process development. I have demonstrated my commitment to both academic and industrial research, and various product development programs.
I am presently seeking a position as a Scientist, aiming to apply my expertise in assisting clients and contributing to the expansion of your organization.
Design, synthesis purification and characterization of of organic compounds for the lead optimization of new drugs, and process development and scale-up synthesis of key organic intermediates in kilogram scale. Design of drug-like molecules (prediction, rationalization and analysis of receptor binding, ligand similarity, affinity, molecular docking, and fixing problems associated to ADME/DMPK, evading off-targets proteins, and in vitro and in vivo assay analysis).
Performed organic synthesis for lead optimization and development of pre-clinical candidates (e.g., GPR6 Inverse agonist (Alzheimer), Kinases inhibitor (Cancer), Renal dehydropeptidase inhibitor (kidney failure), etc.)
Participated in designing and chemical modification of ligands to fix multiple parameters associated with receptor protein binding efficiency, and ADME/DMPK, and safety.
Performed molecular docking to validate appropriate ligands for the binding of target receptor proteins using Schrodinger molecular docking software based on the known crystal structure.
Identified a preclinical candidate and a concern patent was filed.
Identification of another preclinical candidate is under progress and the relevant patent also under preparation.
Designed and synthesized various hyper-branched polyglycerols.
Conducted post-chemical modification on polyglycerols and synthesized a wide range of O-alkyl derivatives to study their de-emulsifying properties.
Developed a standard operation procedure for the controlled synthesis of a lead hyper-branched polyglycerol in a kilogram scale.
Various hyper branched polyglycerols were synthesized to optimize a lead polymer.
Scale-up and process was developed in kilogram scale.
Customed synthesis of specific small compound libraries of novel scaffolds.
Provided services in custom synthesis of specific chemical compound libraries.
Performed multi-step organic synthesis.
Synthesized large number of complex organic molecules for the lead optimization and preclinical studies associated with cardiovascular and CNS drug development conducted by Pfizer, AstraZeneca.
Synthesized Reboxetine (Norepinephrine reuptake receptor inhibitors), benzazepines (selective 5HT antagonists), gamma amino butyric acid derivatives (Gaba receptor inhibitors), boron-based antibacterial agents (Gram-Negative Bacteria inhibitors, conducted Anacor).
Executed scale-up organic synthesis for key intermediates (10 g to 500g) of medicinal chemistry programs.
Developed processes and scale-up, validated, and transferred scale-up procedures on a small scale for the large-scale synthesis of boron-based antibacterial clinical stage organic compound (AN3365).
Performed scale-up synthesis validations and wrote final reports to document results.
Provided services in organic synthesis for the lead optimization of new drugs for various clients.
نظام التوظيف التشغيلي المعتمد على الذكاء الاصطناعي أولاً، الذي يوحّد ويؤتمت دورة التوظيف بالكامل للمؤسسات الحديثة حول العالم.
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