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Senior Scientist I, Antibody Engineering
Job Location:
Job Location:
San Mateo, CA - USA
Monthly Salary:
$ 160000 - 185000
Monthly Salary:
Posted:
15 August 2026 (27 days ago)
Posted:
Application Deadline:
12 November 2026
Application Deadline:
Vacancies:
1 Vacancy
Vacancies:
Job Summary
The role: BigHat Biosciences is seeking an exceptional individual for a Senior Scientist I role on the antibody engineering & binder generation team to serve as a program team lead of therapeutic programs with external and internal partners driving antibody discovery design optimization and characterization.
Key Responsibilities
- Lead cross-functional project teams (including Data Science AI/ML Engineering Protein Sciences Automation) on the execution of rapid iterative multi-objective optimization to identify high-value therapeutic antibodies through gold-standard assays.
- Deeply understand target biology to better design antibodies that meet our candidate profile.
- Contribute expertise in antibody engineering approaches (including humanization liability remediation affinity tuning format engineering etc) to generate and optimize novel antibodies that meet design requirements.
- Collaborate closely with BigHat leadership and other cross-functional team members to ensure a tight linkage between strategy research and development components.
- Lead in-depth data analysis of each design cycle to better leverage experimental and computational approaches to reach our design goals.
- Effectively and regularly communicate results to key decision makers the broader BigHat team and to external partners.
Skills Knowledge and Expertise
- Ph.D. in biochemistry structural biology protein engineering or related fields.
- 5 years of advanced research experience in an industry setting.
- Hands-on protein engineering expertise including structure-guided design affinity maturation stability/developability optimization and rational or computational approaches to antibody engineering.
- Experience working with diverse antibody formats such as complex multispecifics T-cell engagers antibody fragments antibody-drug conjugates etc.
- Expertise in mammalian cell culture immunoassay molecular techniques cell-based assays protein expression and characterization (e.g. kinetics SEC).
- Exceptional written verbal and visual communication skills.
- Experience presenting and communicating strategy and results to internal and external partners.
- Scientific track record and publication record.
- Strong data analysis and interpretation skills. Experience working with agentic software tools is a plus.
Total Rewards
The salary estimated for this position is $160000 - $185000 bonus options benefits. Compensation will vary depending on job-related knowledge skills and experience. Actual compensation will be confirmed in writing at the time of the offer.
Required Experience:
Senior IC
About Company
BigHat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology. BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these desig ... View more
