Senior Scientist, Analytical Chemistry
Job Location:
Job Location:
Cambridge, MA - USA
Monthly Salary:
$ 150000 - 180000
Monthly Salary:
Posted on:
30+ days ago
Posted on:
Vacancies:
1 Vacancy
Vacancies:
Job Summary
About Us
Deep Genomics is at the forefront of using artificial intelligence to transform drug discovery. Our proprietary AI platform decodes the complexity of RNA biology to identify novel drug targets mechanisms and therapeutics inaccessible through traditional methods. With expertise spanning machine learning bioinformatics data science engineering and drug development our multidisciplinary team in Toronto and Cambridge MA is revolutionizing how new medicines are created.
Opportunity
This role based in Cambridge MA is focused on the analytical characterization and formulation of oligonucleotides in support of the research efforts at Deep Genomics. The individual in this role will assure the identity and purity levels of oligonucleotides as they are obtained from external CROs as well as from pre-clinical in vitro and in vivo metabolism experiments. The person in this role will also be responsible for the formulation of oligonucleotides for in vitro and in vivo experimentation. Further responsibility for the management of research samples falls within the remit of this role.
Key Responsibilities
- Working with the leader of Molecular Design Chemistry develop and implement a plan for the installation of an LCMS system for analysis of oligonucleotides.
- Maintain as superuser an LCMS system for the characterization of oligonucleotides for identify purity and stability.
- Develop analytical methods for the LCMS system to characterize research oligonucleotide samples including characterization of chemical and metabolic stability.
- Maintain efficient workflows combining internal and external analytical work at CROs.
- Generate Certificate of Analysis reports from such data.
- Perform formulation processes to provide research samples ready for in vitro and in vivo experimentation including endotoxin analysis.
- Develop and maintain a sample tracking system for the compounds that come into Deep Genomics at Cambridge.
- Future responsibilities may include bioanalysis of PK samples.
Basic Qualifications
- PhD in analytical pharmaceutical sciences or bio-organic chemistry including expertise in HPLC (high pressure liquid chromatography) and mass spectrometry with 2 years experience; MS in similar fields with 5 years experience.
- Experience in the laboratory techniques for oligonucleotides.
- Experience in designing and implementing new processes for oligonucleotide samples.
Preferred Qualifications
- Experience with oligonucleotide therapeutics including formulation.
- Understanding of in vitro assays and/or in vivo experiment involved in ADAR siRNA and ASO-modality therapeutics.
- Experience in bioanalysis and GxP methods and laboratory operations would be a benefit.
What We Offer
- A collaborative and innovative environment at the frontier of computational biology machine learning and drug discovery.
- Highly competitive compensation including meaningful stock ownership.
- Comprehensive benefits - including health vision and dental coverage for employees and families employee and family assistance program.
- Flexible work environment - including flexible hours extended long weekends holiday shutdown unlimited personal days.
- Maternity and parental leave top-up coverage as well as new parent paid time off.
- Focus on learning and growth for all employees - learning and development budget & lunch and learns.
- Facilities located in the heart of Toronto - the epicenter of machine learning and AI research and development and in Kendall Square Cambridge Mass. - a global center of biotechnology and life sciences.
Deep Genomics encourages applications from all backgrounds who seek the opportunity to build the worlds leading AI-driven genetic medicine company.
If you have a disability or special need accommodation is available on request for candidates taking part in all aspects of the selection process.
*This posting reflects a current vacancy.
We offer competitive compensation aligned with local market benchmarks. The salary range for this role is $150000 - $180000 and reflects Cambridge USA-based roles; compensation may differ for Canada-based candidates.
We may use artificial intelligence (AI) tools to support parts of the hiring process such as reviewing applications analyzing resumes or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed please contact us.
Required Experience:
Senior IC
About Company
Revolutions in AI, biology and automation are enabling a new approach to medicine. Deep Genomics is at the forefront.
