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Senior Manager, P2P Process & Platform Enablement


Job Location:

Boston, MA - USA

Yearly Salary: USD 135400 - 203100
Posted: 13 September 2026 (12 hours ago)
Application Deadline: 11 December 2026
Vacancies: 1 Vacancy

Job Summary

Job Description

Role Summary

The Senior Manager P2P Process & Platform Enablement is responsible for leading and advancing Procure-to-Pay (P2P) execution enablement serving as a senior business lead for the platform processes and controls that support compliant efficient purchasing and supplier transactions.

This role leads the business-side enablement of P2P execution across requisitioning approvals catalogs purchase orders receiving invoice processing and matching and Supplier Information Management (SIM). The role helps ensure P2P execution is stable well-controlled scalable and continuously improved leveraging best in class practices and AI. Partners closely with Procurement Operations Finance/AP IT/Digital and other COE towers to deliver reliable outcomes improving UX.

Key Responsibilities

1. P2P Process & Platform Ownership

  • Serve as a senior business lead for P2P execution processes and enabling platforms including requisitioning approvals catalogs PO creation and changes receiving invoice capture and matching and operational payment handoffs.
  • Lead the Supplier Information Management (SIM) operating model including supplier onboarding profile maintenance and execution workflows in partnership with operations and data stewards.
  • Drive a controlled end-to-end lifecycle for P2P execution including matching logic exception handling and audit-ready traceability within the broader S2P system architecture.

2. Enablement Roadmap & Continuous Improvement

  • Lead the enablement roadmap and backlog for P2P processes and platforms including enhancements configuration changes and defect remediation.
  • Prioritize work based on business value compliance risk operational efficiency and user experience.
  • Drive continuous improvement across cycle times exception volumes guided buying adoption catalog usage and compliance outcomes.
  • Embrace and leverage best in class processes & AI solutions to drive the enablement roadmap and deliver on continuous improvement targets

3. Change Release & Readiness Management

  • Lead business-side change and release readiness activities including impact assessment testing coordination UAT and go-live preparation.
  • Ensure changes & releases do not disrupt purchasing invoice processing supplier workflows or downstream financial execution.
  • Partner with IT and operations to manage issues escalations and postdeployment stabilization.

4. Controls Compliance & Operational Integrity

  • Advance P2P workflows configurations and routing models that support and operationalize required controls approvals receiving matching tolerances and exception governance.
  • Partner with Finance/AP and Compliance to support audit requirements and reduce offpolicy or offcontract spend while leveraging optimal payment terms and catalog utilization.

5. Supplier Enablement & Data Quality

  • Lead supplier enablement efforts to support efficient onboarding and accurate supplier information throughout the lifecycle.
  • Partner with MDM Data Governance and Operations teams to ensure supplier data completeness accuracy and stewardship exist within all P2P tools.

6. Operating Model with Procurement Operations and other S2P teams

  • Partner with Procurement Operations and any execution or BPO teams supporting P2P activities to maintain clear operating rhythms.
  • Define escalation paths issue resolution processes and continuous improvement loops to reduce friction and improve service levels (SLAs) with upstream & downstream stakeholders including sourcing contracting TPRM and AP.

7. CrossCOE Collaboration (Clear Boundaries)

  • Partner with Strategy Governance & Excellence to operationalize standards and policies within P2P execution.
  • Partner with User Orchestration to ensure intake and buyingchannel decisions flow cleanly into P2P execution.
  • Partner with Analytics and Master Data teams to ensure execution & transactional data supports trusted KPIs and decisiongrade insights.

Qualifications & Experience

Required:

  • 8 years of experience supporting and enabling Procure-to-Pay processes and platforms in a business COE or product ownership role.
  • Strong understanding of endtoend P2P execution including requisitioning approvals PO management receiving invoice processing and matching.
  • Handson experience leading requirements definition UAT enablement enhancements and user training.
  • Expert Change Agent with demonstrable skills in planning communicating and executing platform releases enhancements and configuration changes with various cross-functional teams.
  • Extensive deployment and utilization of AI RPA OCR and other cutting-edge technologies & capabilities within the P2P space

Preferred:

  • Experience driving P2P automation and reducing operational friction particularly in invoice matching and exception handling.
  • Experienced leading Coupa and SIM
  • Experience partnering with ERP and Accounts Payable teams to support stable financial execution.
  • Exposure to various P2P platform integrations including Contingent Labor tools CLMs MDM and TPRM.
  • Familiarity with structured enablement training or credentialing models for P2P platforms.

Leadership Attributes

  • Execution-oriented lead with a balance of operational stability and continuous improvement
  • Strong cross-functional influencer and advisor able to drive outcomes without direct authority.
  • Embraces modern tools and technologies to drive change
  • Clear communicator who translates business needs into executable process and platform outcomes.

#LI-Hybrid

#LI-AA1


At Vertex we embrace continuous learning and encourage employees to stay informed on advances in AI technology automation and industry trends. We seek talent who bring an external perspective demonstrate curiosity and sound judgment and thoughtfully adopt new capabilities that improve decision-making drive innovation increase efficiency and help deliver better outcomes for patients.

Pay Range:

$135400 - $203100

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors including skills competencies experience and other job-related factors permitted by law.

At Vertex our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career financial family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter) educational assistance programs including student loan repayment a generous commuting subsidy matching charitable donations 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.

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Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at


Required Experience:

Senior Manager


About Company

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Vertex Pharmaceuticals invests in scientific innovation to create transformative medicines for people with serious diseases.

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