Senior Lab Operations Specialist, Research Lab Operations

Revolution Medicines is a global commercial-state oncology company dedicated to discovering developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform the company is advancing a broad integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active cancer-driving state of on rigorous scientific inquiry and a willingness to challenge long-held assumptions Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science challenge assumptions act with urgency and hold ourselves to a high standard of rigorall in service of patients.

The Opportunity:

Revolution Medicines is seeking an experienced in vivo research and laboratory operations professional with a strong background in rodent oncology models and vivarium operations. This senior-level position will independently lead the planning and execution of complex in vivo pharmacology studies in mice provide day-to-day scientific and operational leadership for research associates and serve as a key partner to scientists and cross-functional project teams. The role will help ensure consistent high-quality study execution and support the continued growth and operational excellence of the vivarium. This position will also provide management oversight for weekend and holiday animal operations and serve as an escalation point for study facility and animal welfare issues.

• Independently plan coordinate conduct analyze and report complex in vivo pharmacology studies including efficacy and PK/PD studies.

• Manage supervise train and develop research associates; delegate work establish expectations provide feedback and ensure consistent technical performance.

• Coordinate study staffing scheduling and resources across concurrent studies to ensure timely execution while maintaining animal welfare and data quality.

• Provide oversight of weekend and holiday animal operations and serve as an escalation point for unexpected study animal welfare staffing or facility issues.

• Drive continuous improvement of vivarium workflows and SOPs; identify operational risks and implement practical solutions that improve consistency efficiency and study quality.

• Ensure appropriate SOPs animal welfare guidelines IACUC requirements and applicable regulations are followed by vivarium users.

• Troubleshoot complex in vivo procedures study execution issues and facility or animal welfare concerns; communicate issues and recommended actions to appropriate stakeholders. Provide technical guidance on feasibility and execution of in vivo studies.

Required Skills Experience and Education:

• BS or MS in Biology Pharmacology or a related discipline with approximately 8 years of relevant in vivo research experience or an equivalent combination of education and experience.

• Demonstrated ability to independently lead complex in vivo pharmacology studies from planning and resource coordination through execution analysis and reporting.

• Advanced proficiency with mouse handling techniques including dosing (IV PO SC IP) tumor inoculation and measurements in-life and terminal blood collection survival surgeries necropsy and tissue processing for ex vivo analysis.

• Significant research experience with mouse models of cancer.

• Demonstrated experience supervising training or leading research associates and coordinating work across multiple team members.

• Excellent communication and collaboration skills including the ability to provide clear operational guidance and work effectively with multidisciplinary project teams.

• Demonstrated ability to work independently make sound day-to-day decisions and take ownership of research and operational goals.

• Proficiency with Excel PowerPoint and Word.

Preferred Skills:

• Experience with Studylog Prism and Benchling.

• Rodent surgical experience including orthotopic tumor models.

• Sterile tissue culture experience.

• Familiarity with sample collection and processing for IHC and cellular/molecular biology assays such as FACS western blot and qPCR.

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