Senior Director, In Vivo Pharmacology

The Role:

Gnerate:Biomedicines is a new kind of therapeutics company at the intersection of machine learning biological engineering and medicine pioneering Generative Biology to create breakthrough medicines where novel therapeutics are computationally generated rather than discovered.

We are seeking a Senior Director In Vivo Pharmacology to provide scientific and organizational leadership for in vivo pharmacology and help advance a growing portfolio of novel biologic medicines from early discovery through development.

Reporting to the Head of Preclinical Pharmacology this individual will lead and develop a team of in vivo pharmacology scientists while shaping and executing in vivo pharmacology strategies across close partnership with Preclinical Pharmacology Early Biology and other scientific and development functions the Senior Director will ensure that in vivo studies are tightly connected to mechanistic understanding in vitro functional and high-throughput data and emerging translational evidence.

The Senior Director will also work closely with the translational biology function to help establish and incorporate appropriate human experimental systems and New Approach Methodologies (NAMs) into preclinical pharmacology strategies where they can add value. This will complement and inform traditional in vitro and in vivo approaches and help strengthen the connection between preclinical findings and human biology for more informative and successful FIH studies.

This role sits at the intersection of scientific strategy experimental execution and organizational leadership. The Senior Director will connect technology and mechanism to pharmacology pharmacology to translation and experimental evidence to program decisions. They will work across functions to ensure that pharmacology strategies are rigorous appropriately quantitative and aligned with development objectives and regulatory expectations.

The successful candidate will bring deep expertise in in vivo pharmacology and drug development strong scientific judgment and a demonstrated track record of building and developing high-performing scientific teams. Equally important they will thrive in an environment that values scientific rigor innovation thoughtful experimentation collaboration transparency and the willingness to challenge conventional approaches in pursuit of better medicines for patients.

Heres how you will contribute:

Scientific and Strategic Leadership

Provide strategic and scientific leadership for in vivo pharmacology across discovery and development programs translating program hypotheses into rigorous decision-enabling experimental strategies.

Partner with program and functional leaders to develop integrated pharmacology plans encompassing model selection study design pharmacodynamic and efficacy endpoints dose and schedule optimization and translational strategies.

Critically evaluate the relevance strengths and limitations of in vivo models and develop fit-for-purpose approaches that reflect disease biology mechanism of action therapeutic modality and stage of development.

Integrate in vivo pharmacology and PK/PD findings with in vitro functional and high-throughput data translational biology biomarkers safety and other relevant datasets to build a cohesive understanding of therapeutic activity and inform candidate progression.

Apply strong scientific judgment to complex and ambiguous datasets identifying key risks knowledge gaps and opportunities for experiments or technologies that can efficiently resolve uncertainty.

Serve as a senior pharmacology partner on cross-functional program teams influencing program strategy and communicating scientific recommendations clearly to scientific and organizational leadership.

Ensure that pharmacology strategies evolve with program maturity from early mechanism and proof-of-concept through candidate selection IND-enabling studies and first-in-human development.

Coach and develop direct reports through regular feedback career development scientific mentorship and opportunities to expand their technical and leadership capabilities while helping them define and pursue meaningful career paths within the organization.

Work closely with the translational biology team to help incorporate relevant human experimental systems including NAMs when appropriate and contribute in vivo pharmacology expertise to the development and interpretation of translational strategies.

Identify opportunities to strengthen the connection between preclinical pharmacology findings and human biology clinical hypotheses and development decisions.

Scientific Excellence and Execution

Drive high standards for experimental design data quality reproducibility documentation quantitative analysis and scientific interpretation across internal and external in vivo studies.

Identify opportunities to expand and evolve Generates in vivo pharmacology capabilities including new models technologies quantitative approaches and experimental strategies.

Establish and oversee productive relationships with CROs and external research partners ensuring scientific quality operational excellence and alignment with program objectives.

Foster transparent and courageous communication encouraging the team to surface risks uncertainties and differing scientific perspectives early and use evidence to reach well-reasoned decisions.

Contribute in vivo pharmacology expertise to regulatory and development activities including the preparation and review of relevant scientific and regulatory documentation.

Communicate complex scientific findings and recommendations to audiences with varying technical backgrounds clearly distinguishing evidence interpretation uncertainty and recommended next steps.

Leadership Responsibilities

As Senior Director In Vivo Pharmacology you will lead and develop a team of in vivo pharmacology scientists and help build a critical capability within Preclinical Pharmacology. You will have accountability for the teams scientific strategy performance capabilities and development.

Lead manage and develop a high-performing team of scientists responsible for in vivo pharmacology across Generates portfolio establishing clear roles priorities and expectations.

Recruit and retain exceptional scientific talent and build the capabilities and expertise required to support both the current portfolio and Generates evolving scientific needs.

Set a high bar for scientific rigor execution accountability and collaboration ensuring that team members understand how their work connects to program functional and company objectives.

Coach and develop direct reports through regular feedback career development scientific mentorship and opportunities to expand their technical and leadership capabilities.

Develop future leaders within the team and appropriately delegate scientific and organizational ownership creating an organization that can operate effectively as the portfolio grows.

Create an inclusive environment in which scientists are empowered to challenge assumptions debate scientific hypotheses take thoughtful risks and learn openly from both successful and unsuccessful experiments.

Establish effective operating mechanisms for prioritizing resources and studies across programs balancing portfolio needs scientific opportunities team capacity and timelines.

Foster the development of scientific talent across the broader Preclinical Pharmacology organization providing mentorship and sponsorship to early- and mid-career scientists and creating opportunities for them to expand their scientific judgment technical expertise visibility and leadership capabilities.

Partner with the Head of Preclinical Pharmacology to define functional priorities evolve capabilities allocate resources and ensure that in vivo pharmacology operates as an integrated scientific partner rather than a downstream execution function.

Collaborate closely with the translational biology leader and other peer functional leaders to ensure effective integration of in vivo pharmacology with broader preclinical and translational strategies.

Partner with peer leaders across Generate to ensure that the organization is positioned to meet the evolving needs of the portfolio and to build capabilities that scale with the company.

Model adaptability accountability and resilience as programs hypotheses and organizational priorities evolve while maintaining a strong commitment to scientific rigor and innovation.

The Ideal Candidate will have:

PhD in Pharmacology Biology Immunology Oncology Neuroscience or a related scientific discipline with 12 years of relevant experience in biotechnology or pharmaceutical drug discovery and development including significant experience leading and developing scientific teams.

Deep expertise in in vivo pharmacology with demonstrated experience designing interpreting and integrating pharmacology studies that inform drug discovery and development decisions.

Broad understanding of the relationships among disease biology mechanism of action exposure target engagement pharmacodynamics efficacy and translational relevance.

Demonstrated ability to develop in vivo strategies for complex therapeutic programs and select fit-for-purpose models based on scientific evidence mechanism therapeutic modality and development objectives.

Experience advancing therapeutic candidates through key discovery and preclinical development milestones.

Strong understanding of experimental design quantitative data interpretation and the strengths limitations and translational relevance of preclinical models.

Experience across multiple therapeutic modalities; experience with biologics development is highly valuable.

Demonstrated ability to integrate complex datasets and translate them into clear scientific conclusions program implications and actionable recommendations.

Significant experience leading managing and developing scientists in a high-performing multidisciplinary industry research environment.

Demonstrated success recruiting talent setting performance expectations coaching team members and developing scientific and leadership capabilities.

Track record of effective scientific leadership on multidisciplinary drug discovery or development teams.

Ability to influence decisions across organizational boundaries through scientific credibility sound judgment and clear communication.

Experience managing external research partnerships and CRO relationships.

Strong written and verbal communication skills including the ability to present complex scientific information and recommendations to senior scientific and business leaders.

A collaborative leadership style and demonstrated commitment to scientific rigor transparency accountability and continuous learning.

Nice to Have

Experience developing pharmacology strategies for novel or emerging biologic modalities.

Experience contributing to IND-enabling programs and regulatory submissions.

Expertise in translational pharmacology PK/PD biomarkers or quantitative approaches for connecting preclinical findings with clinical hypotheses.

Experience establishing or scaling in vivo pharmacology capabilities platforms or teams within a growing biotechnology organization.

Familiarity with human experimental systems New Approach Methodologies (NAMs) or other approaches that can complement traditional preclinical models.

Experience using computational data-driven or technology-enabled approaches to improve experimental design model selection or interpretation of pharmacology data.

Scientific contributions demonstrated through publications patents external presentations or other evidence of leadership within the field.

Who Will Love This Job:

This is an opportunity to help define how in vivo pharmacology contributes to a fundamentally different approach to creating medicines.

At Generate computationally generated proteins give us the opportunity to explore therapeutic design space in ways that traditional discovery approaches cannot. Realizing that potential requires equally rigorous experimental science: asking the right biological questions designing studies that meaningfully test our hypotheses and integrating diverse datasets to generate insights that can move promising medicines toward patients.

As Senior Director In Vivo Pharmacology you will have the opportunity to shape that work at both the scientific and organizational levels. You will build and develop the team and capabilities needed for a growing portfolio influence programs across stages of discovery and development and work closely with scientists across Generate to connect in vitro and in vivo pharmacology with broader translational strategies.

We are looking for a leader who is deeply scientific relentlessly curious comfortable challenging assumptions and energized by the opportunity to build a strong cutting edge in vivo pharmacology capability that helps translate Generates Generative Biology platform into meaningful medicines.

About Generate:Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creationone grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation this approach aims to reduce the uncertainty time and cost associated with developing protein-based medicines.

Founded in 2018 we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need faster guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Companys internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

#LI-RT1