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Senior Applied AI Bioinformatician
Job Location:
Monthly Salary:
Posted:
13 August 2026 (23 days ago)
Posted:
Application Deadline:
10 November 2026
Application Deadline:
Vacancies:
1 Vacancy
Vacancies:
Job Summary
Sequencing is building the interface between humanity and its DNA.
Using clinical-grade whole genome sequencing AI and a rapidly expanding ecosystem of genomic applications we help people better understand themselves their health and their future through their DNA.
The human genome is one of the most valuable and underutilized resources in the world. Our mission is to transform the human genome into a lifelong source of personalized guidance and build the trusted home for every genome on Earth.
As the worlds largest direct-to-consumer whole genome sequencing platform Sequencing is helping define the future of AI-powered personalized health.
Were a profitable venture-backed fully remote company building category-defining products that help people better understand themselves through their DNA.
The opportunity
As Senior Applied AI Bioinformatician you will discover and prove new genetically enabled capabilities for Sequencings products and broader intelligence layer.
Reporting: This role reports to the Senior Director AI & Emerging Technologies.
This is a hands-on senior individual-contributor role for a genuinely strong bioinformatician who thinks and builds agentically. You will explore new ways to combine genetic data scientific knowledge retrieval tools computational methods and AI reasoning to create useful capabilities that are not possible today.
Examples could include a new bioinformatics skill a genomic retrieval or interpretation component or an evidence-synthesis workflow that expands what Sequencings AI products can do.
You will take promising ideas from scientific hypothesis through working prototype. For each proposed bioinformatics capability you will define the user value required data underlying genetic premise scientific uncertainty evaluation plan and evidence needed to advance narrow or stop the work. You will partner with Product and Engineering to turn validated ideas into scalable capabilities while independent scientific evaluation remains a separate release safeguard.
This is a 0-to-1 exploration role not the ongoing owner of production model quality. Bioinformatics retains ownership of benchmark maintenance independent scientific evaluation ongoing quality monitoring release readiness and scientific reliability. Your job is to open new possibility space prove or disprove ideas quickly and hand off evidence-backed capabilities for independent evaluation and productionization.
What youll own
A portfolio of bounded exploratory projects that test new bioinformatics capabilities for Sequencings AI products and broader intelligence layer.
Scientific hypotheses that connect a meaningful user need to a defensible genetic premise and an achievable computational approach.
Hands-on prototypes combining genomic data scientific literature and knowledge retrieval or query tools deterministic methods and model reasoning.
Explicit uncertainty boundaries contraindications data limitations failure modes and stop conditions for each proposed capability.
Diagnosis of failures across source data bioinformatics processing retrieval and tool use model reasoning and orchestration during exploration and prototyping.
Evidence packages that allow Product Engineering Bioinformatics and independent evaluators to decide whether a capability should stop be revised or advance into independent evaluation.
Clear handoffs to the AI Platform PM Engineering and Bioinformatics when a prototype has enough evidence to enter independent scientific evaluation and potential productionization.
Ongoing awareness of Sequencings bioinformatics systems and capabilities through deep working partnership with the Bioinformatics team.
Use of evaluation findings customer questions scientific developments and production evidence as inputs to new hypotheses and prototype revisions without owning the production quality loop.
What you will not own
Ongoing ownership of production model quality benchmark datasets independent scientific evaluation release readiness or production scientific reliability. These remain with Bioinformatics and the designated quality owner.
Independent scientific evaluation or final validation of your own work.
Production release approval for scientific accuracy or safety.
General backend-engineering delivery that belongs in the separate AI Bioinformatics Engineering search.
Broad Bioinformatics organizational leadership or people management.
Who you are
You have deep professional expertise in bioinformatics computational genomics statistical genetics or a closely related field.
You can evaluate the genetic premise evidence quality uncertainty and limitations behind a proposed capability.
You build hands-on with modern AI tools and can show how you have used models agents retrieval tools structured data or computational pipelines to investigate or prototype scientific work.
You understand that using AI is different from building a reliable AI system and can explain validation guardrails failure handling and human review.
You can distinguish failures in data availability bioinformatics processing retrieval model reasoning and orchestration.
You design reproducible experiments with explicit success criteria negative controls uncertainty and advance or stop evidence.
You communicate scientific complexity clearly to Product and Engineering without overstating confidence.
You welcome independent review and can change course when evidence does not support a hypothesis.
You are energized by 0-to-1 scientific exploration and evidence-backed handoffs rather than ongoing ownership of production model quality.
You are based in the United States and comfortable operating as a senior individual contributor in a fast-moving fully remote environment.
Helpful experience
Consumer genomics clinical genomics variant interpretation polygenic risk pharmacogenomics or genomic knowledge systems.
Production LLM evaluation retrieval-augmented generation agentic systems or scientific tool use.
Translating research prototypes into reliable product or platform capabilities.
Health-product safety regulated environments or scientific release governance.
Benefits overview
Comprehensive medical dental and vision insurance coverage
401(k) with company matching
Paid time off (PTO)
Paid volunteer time off
Fully remote work with home office stipend
Parental bonding leave
Clinical-grade whole genome sequencing for you and your family (private and confidential)
Join Sequencing
Redefine how people understand themselves through their DNA
Build category-defining products alongside scientists engineers and innovators
Contribute to technology that will improve and extend millions of lives
Shape one of the most important emerging categories in AI and healthcare
Sequencing Inc. is an equal opportunity employer. All aspects of employment including the decision to hire promote discipline or discharge will be based on merit competence performance and business needs. We do not discriminate based on race color religion marital status age national origin ancestry physical or mental disability medical condition pregnancy genetic information gender sexual orientation gender identity or expression veteran status or any other status protected under federal state or local law. Where required by applicable law candidates may request a reasonable accommodation or an alternative selection process by contacting
Required Experience:
Senior IC
