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Scientist II, Developability
Job Location:
Job Location:
San Mateo, CA - USA
Monthly Salary:
$ 145000 - 165000
Monthly Salary:
Posted:
14 June 2026 (30+ days ago)
Posted:
Application Deadline:
11 September 2026
Application Deadline:
Vacancies:
1 Vacancy
Vacancies:
Job Summary
The Role: BigHat Biosciences is looking for a hands-on bench-driven scientist to drive antibody developability assessments that advance our Milliner Platform for AI-designed therapeutics. This is a primarily lab-based role where youll spend the majority of your time at the bench executing and innovating on our developability workflows.
*At BigHat we believe in titles that commensurate with skill set relative organizational impact and value contribution; more experienced candidates are encouraged to apply with the understanding that
*At BigHat we believe in titles that commensurate with skill set relative organizational impact and value contribution; more experienced candidates are encouraged to apply with the understanding that
responsibilities and title would adjust as appropriate.
Key Responsibilities
- Lead developability R&D projects: design optimize and execute high throughput developability assays to expand BigHats toolkit.
- Drive developability assessments (purity stability tolerability biophysical properties) across programs with strong attention to data interpretation and organization.
- Support late-stage characterization and IND-enabling studies including formulation screening stress testing peptide mapping and simulated administration studies to rank and advance lead candidates.
- Serve as the Developability lead within project teams guiding experimental strategy to address liabilities and hit program milestones.
- Work cross-functionally to automate and train colleagues on new and existing methods build QC frameworks for monitoring assay performance and adapt workflows to existing LIMS infrastructure.
- Proactively and independently analyze data interpret scientific findings propose next steps and broadcast findings clearly across the organization.
Skills Knowledge and Expertise
- PhD in Biochemistry or relevant discipline with 3 year(s) of industry experience; exceptional non-PhD candidates with deep bench experience will be considered.
- Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC HIC CE-SDS DLS DSF ELISA LC-MS including method development and optimization.
- Track record of translating complex data into clear results and recommended actions.
- Experience with protein structures and antibody engineering.
- Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality timelines throughput or cost.
- Nice-to-haves include prior experience working in a dynamic start-up environment working as a project lead and working with automation.
Total Rewards
The salary estimated for this position is $145000 - $165000 bonus options benefits. Compensation will vary depending on job-related knowledge skills and experience. Actual compensation will be confirmed in writing at the time of the offer.
What BigHat Offers:
What BigHat Offers:
- Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
- Dental and vision coverage through Guardian
- Additional well-being benefits through Nayya OneMedical Wagmo Rula and more
- 401(k) with company match
- DTO two weeks of company-wide shutdown and 12 company holidays
- Paid parental leave
Required Experience:
IC
About Company
BigHat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology. BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these desig ... View more
