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About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at

We are searching for the best talent for a Principal Scientist Immunopeptidomics to be located in Cambridge MA.

Purpose: Do you want to use your hardearned skills and drive to make a difference in the lives of patients Join the growing Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery to apply groundbreaking approaches to highscale proteomic analysis! Be part of a motivated team deploying innovative mass spectrometry technologies to tackle challenges in endtoend drug discovery and development across a leading multiomics organization. We work shouldertoshoulder across biology chemistry and data science to deliver clear reproducible proteomic readouts that move medicines forward. With your help we will drive development of medicines for our patients!

Lead the development and delivery of immunogenicity assays supporting discovery programs across the Innovative Medicine portfolio. You will focus on handson assay development highthroughput screening and data generation while working closely with diverse teams of protein engineers data scientists and biologists.

You will be responsible for:

• Leading must-win immunogenicity projects across biologics CAR-T and peptide therapeutics from early discovery through candidate selection.
  
• Owning the design implementation and execution of novel high throughput assays; continuously improving. methods and workflows to enhance efficiency and quality.
  
• Translating assay results into clear decision-enabling interpretations for program and engineering teams. Ensuring strong data integrity documentation and reproducibility.
  
• Driving rapid innovation and providing technical leadership while building strong multi-functional relationships as a scientific partner.
  
• Developing and operationalizing population-aware immunogenicity risk assessment strategies ensuring consistent application across programs and integration within discovery and engineering cycles.
  

Qualifications / Requirements

Education:

• PhD in Immunology Biochemistry Cellular/Molecular Biology Bioengineering or a related field is required.
  

Experience and Skills:

Required:

• 6 years of proven biotech or pharmaceutical experience is required.
  
• Demonstrated expertise in immunology with hands-on experience developing implementing and interpreting complex immune cell-based assays is required.
  
• Strong cross-functional communication skills with the ability to translate multi-dimensional datasets into a decision-relevant narrative is required.
  

Preferred:

• Hands on experience with LC-MS instrumentation in support of immunopeptidomics workflows is preferred.
  
• Experience developing high-throughput assay workflows from pilot to scalable routine deployment is preferred.
  
• Hands-on experience with integrated lab automation systems is preferred.
  
• Familiarity with therapeutic engineering concepts is desirable.
  
• Experience working with in silico tools and integrating computational outputs with experimental data is preferred.
  
  

The anticipated base pay range for this position is $117000 to $201250.

The Company maintains highly competitive performance-based compensation programs. Under current guidelines this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporations performance over a calendar/performance year. Bonuses are awarded at the Companys discretion on an individual basis.

• Subject to the terms of their respective plans employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical dental vision life insurance short- and long-term disability business accident insurance and group legal insurance.
  
• Subject to the terms of their respective plans employees are eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).
  
• Subject to the terms of their respective policies and date of hire Employees are eligible for the following time off benefits:
  
  • Vacation 120 hours per calendar year
    
  • Sick time - 40 hours per calendar year; for employees who reside in the State of Washington 56 hours per calendar year
    
  • Holiday pay including Floating Holidays 13 days per calendar year
    
  • Work Personal and Family Time - up to 40 hours per calendar year
    
  • Parental Leave 480 hours within one year of the birth/adoption/foster care of a child
    
  • Condolence Leave 30 days for an immediate family member: 5 days for an extended family member
    
  • Caregiver Leave 10 days
    
  • Volunteer Leave 4 days
    
  • Military Spouse Time-Off 80 hours
    

Additional information can be found through the link below.

For additional general information on Company benefits please go to:

The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.

This job posting is anticipated to close on 06/02/2026. The Company may however extend this time-period in which case the posting will remain available on to accept additional applications.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.

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