Late-Stage LNP Process Development Scientist

As a member of the Late-Stage LNP Process Development team the candidate will be joining a team conducting laboratory studies to support the process development process scale-up and process characterization of LNP clinical stage drug products. The successful candidate will have experience with LNP process development (having additional experience in tech transfer and GMP manufacturing is a plus but not required) and a desire to contribute to a team focused on establishing science-based manufacturing solutions for complex nucleic acid-based drug this highly collaborative and cross-functional role the candidate will support the refinement of process control and improve process understanding for multiple programs at various stages of clinical development.

• Support routine process development and process characterization activities centered around the LNP drug product manufacturing process. Batch ranges vary from 10 mg to 1 gram.
• Execute routine analytics including dynamic light scattering (DLS) UV-quantification via Ribogreen pH and osmolality for in-process monitoring.
• Perform experiments under limited to no supervision under subject matter expert guidance.
• Organize and analyze data interpret results and present findings within the process development team and cross-functionally.
• Author technical documentation (SOPs reports protocols) as required.
• Document experiments and protocols using electronic lab notebooks (e.g. Benchling).
• Maintain laboratory equipment order critical reagents and support operational excellence activities.

Qualifications :

Minimum Required Qualifications:

• B.S. degree in chemical/biomedical engineering chemistry or biological sciences (or related field) with 3-4 years of relevant laboratory experience. M.S. degree in biological or biochemical sciences (or related field) with 1-2 years of relevant laboratory experience. 
• Proficiency in bench-scale drug product manufacturing of LNPs with a focus on mixing and tangential flow filtration (TFF) processes.
• Experience with practices and equipment used in process development of nucleic acids (experience with T-mixing and TFF is preferred).
• Experience with DLS and osmolality for in-process monitoring.
• Experience working with ELN systems such as Benchling.
• Experience with technical documentation (SOPs technical reports protocols).
• Ability to follow established SOPs for routine analytics.
• Ability to achieve results keep to a timeline and find solutions to ensure that overall project deliverables are met.
• Strong attention to detail analysis of data/reports troubleshooting and problem-solving abilities.
• Strong writing and communication skills with the ability to understand and communicate scientific information.
• Strong organizational and time management skills.
• Willingness to collaborate with cross-functional teams.
• Proactive creative and positive attitude.

Preferred Qualifications:

• Experience with UV-quantification via Ribogreen.
• Experience with GMP manufacturing practices and tech transfer operations is a plus.
• Experience with statistical analysis software (i.e. JMP Design Expert etc.) is a plus.
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Additional Information :

The position is full-time Monday-Friday 8am-5pm with overtime as needed. Candidates living within a commutable distance of Boston MA are encouraged to apply.

Excellent full-time benefits include:

• Comprehensive medical coverage dental and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays
• Eligibility for yearly goal-based bonus & merit-based increases
• Compensation: $36.00-$42.00 per hour

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.

Remote Work :

No

Employment Type :

Full-time