Head of AIML Therapeutic Design

Company Description

Metaphore Biotechnologies is a Flagship Pioneering-founded company focused on creating a new class of functional biological therapeutics. We are pioneering the power of function-first AI drug designand high-throughputdataassaysto make previously intractable drug targets accessible and unlock breakthroughs that outperform todays drugs formaximumpatient impact.

Our computationally driven MIMIC platform is the worlds first structure-independent sequence-to-function platform for protein design. Inspired by nature our mission is to transform patient lives by unlocking the power of biological therapeutics with a new mimic-discovery platform.

Role Summary

Metaphore isseekingan exceptional execution-driven scientist and leader to serve as Head of AI/ML Therapeutic Design driving the next frontier of AI-powered this role you will define the vision and long-term strategy forMetaphoresAI/ML platform while leading a team of experts to build a scalable highperformance AI/ML engine. Working closely with cross-functional drug discovery teams you and your team will translate advances in AI/ML into impactful therapies by delivering actionable molecule key member of the R&D leadership team you will shape how AI/ML transforms every stage of our drug discovery processfrom high-throughputassaydesign and novel therapeutic generation to lead optimizationandcandidatenomination. Thisrole offers a unique opportunity todrive our integrated discovery platform end-to-end and help bring transformative therapeutics from concept to clinic.

Key Responsibilities

• Scientific & Technical Leadership:Deploystate-of-the-artgenerative modelsforde novoproteindesignandmolecule screeningand optimizationfocusing ontimelydrug and trainnewmodelswithaclearpathtowardsprogramimpact and differentiation.

• Strategic Vision:Definethe AI strategyand deploymentfor Metaphore. Overseeat-scale compute infrastructure andpropose collaborativedata acquisition strategies to continuously train evaluate andoptimizeour modelswhileoptimizingcosts andprogramimpact.

• Team Building & Mentorship:Recruit mentor and lead a multidisciplinary team ofcomputationalscientists. Foster a culture of engineering rigor scientific curiosity and bold tech-first as asenior hands-on mentor to nurture and grow the team.

• Platform Operations &LDBT Loop:Partner deeply with our Discovery as well as Biologics & Enabling Technologies teams to seamlessly integrate high-throughput laboratory data into model training accelerating theLearn-Design-Build-Test (LDBT) loop to an industrial anditerativeimprovementsto our AI/ML platform across stakeholders.

• Portfolio Impact:Drive the computational discovery of novel therapeutic candidates across multiple modalities advancing our internal pipeline and strategic partnerships (such as our active pharma collaborations).

• External Engagement:RepresentMetaphoresAI/ML platformexternallyclearly communicating differentiation and value. Cultivate partnerships with leading tech providers cloud computing partners and academic institutions. Publish breakthroughs in top-tier AI conferences and scientific journals.

Required Qualifications

• Advanced degree (PhD preferred) in Computer Science Machine Learning Computational Biology Physics Applied Mathematics orrelateddiscipline.

• 15 years of industry or rigorous academic experience with a proventrack recordof developing and deploying novel deep learning architectures for molecular biology protein design or structural biology.

• Deepexpertisein modern machine learning paradigms (Transformers Diffusion Equivariant architectures) and a strong command ofstate-of-the-arttools including ML-ops.

• Demonstrated experienceleveragingAI/MLreproduciblyand at scaledeliveringimpactin drug discovery contexts.

• Demonstrated experiencewith modernengineeringarchitecturestofacilitaterapid and scalableimplementationand deployment of AI/MLcapabilities.

• Demonstrated experienceleveragingheterogeneoushigh-and small-throughputdatasets to drivemodel development.

• Significant experiencemanaging and scaling high-performing computational teams in a fast-paced matrixed tech-bio or big tech environment.

• A strong publication record in top-tier AI/ML venues ( ICML ICLR) and/or scientific journals (e.g. Nature Science Cell) ora track recordof shipping impactfulwidely usedmodels/software in the biomolecular space.

Values and Behaviors

• We are seeking individuals with an entrepreneurial spiritstrong communicationskills and comfort working in and contributing to a dynamic and cross-functional team environment.

• Ability to translate complex AI concepts to cross-functional stakeholders seamlessly bridging the gap betweencutting-edgecomputational research and wet-lab drug discovery.

• Act decisively and own end-to-end accountability makingtimely data-informed decisions taking responsibility for results anddeliveringcommitments in dynamic environments.

• At Flagship we recognize there is no perfect candidate. If you have some of the experience listed above but not all please apply anyway. Experience comes in manyformsskills are transferable and passion goes a long way.

About FlagshipPioneeringFlagship Pioneering invents and buildsbioplatformcompanies each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000 Flagship has originated and fostered more than 100 scientific ventures resulting in more than$75 billionin aggregate value. The current Flagship ecosystemcomprises43 companies including Moderna (NASDAQ: MRNA) Generate Biomedicines Omega Therapeutics Sana Biotechnology andTesseraTherapeutics.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability genderidentityor Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively FSP) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneerings internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP and FSP will not owe any referral or other fees with respect thereto

The salary range for this role is $350000 - $460000. Compensation for the role will depend on a number of factors including a candidates qualifications skills competencies and experience. Metaphore Biotechnologies Inc. currently offers healthcare coverage annual incentive program retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Metaphore Biotechnologies Inc.s good faith estimate as of the date of publication and may be modified in the future.

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