DirectorSr. Director, Clinical Operations Lead

Company Overview:

Paratus is decoding evolution to discover and develop first-in-class medicines for serious diseases where todays therapies fall short.We are aglobal team of drug hunters dedicated to transforming natures most resilient traits into first-in-class medicines. Our interdisciplinary teams combine AI-powered discovery with deep drug developmentexpertiseto translate these insights into differentiated therapeutic programs.

This is an opportunity to be thefounding clinical operations leaderat a company where your work will shape both the science and the organization.

Position Overview:

As ParatusSciencesfirst dedicated clinical operations hire you will own the end-to-end delivery of our clinical pipeline. This is not a role for a processfollower itis a role for a dynamicbuilder and operatorwho can translate a clinical development strategy into executable programsestablishthe infrastructure that scales with us and lead with equal parts strategic judgment and hands-on accountability.

You will be the operational backbone of our most critical near-term milestones acrosstwopipeline programs. You will define how we work with CROs how we govern our vendors how we manage risk and how we build the team that carries us through Phase 2 and beyond.

This role reports to the Head of Clinical Development and is initially an individualcontributorposition withanopportunityto build and scale the clinical operations team as the pipeline advances.

This position is based inBoston Massachusetts with an expectation of working in theofficea minimum oftwo days per week.Flexibility to work across global time zones is.

Role Description:

Study Execution & CRO Governance
Lead the full lifecycle of clinical trial executionfrom CRO and vendor selection through contracting study startup site management oversight and study close-out. Own the sponsor-side CRO relationship across the current pipeline including our lead Phase 1 FIH program (healthy volunteersand patients) and the next program advancing toward IND and FIH with accountability for timelines budgets and quality study feasibility develop cost estimates and provide input into contracts work orders and change orders in support of outsourcing decisions.

Create and execute clinical operational strategic plans aligned with product strategy and resource allocation translating developmentobjectivesinto executable resourced program plans.

Operational Infrastructure
Build the clinical operations foundation Paratus will scale on: SOPs vendor qualification frameworks oversight plans and a risk-based monitoring approach. You willestablishpractices that are fit-for-purpose today and structured to grow as the pipeline expands.

Budget & Finance Partnership
Manage clinical trial budgets and forecasts across programs. Partner closely with Finance on accruals variance analysis and program-level cost accountability. Proactively flag risks before they become surprises.

Risk Management & Program Momentum
Develop and execute risk mitigation strategies that protect program timelines. Represent clinical operations in cross-functional program discussions;serving as the operational voice on timelines risks trade-offs and decisions.

Team Building
Identify recruit and develop theClinOpsteam as the pipeline scalesincludingCTMs CRA oversight study managers and beyond. Model a high-performance culture that is inspection-ready compliant and mission-driven.

Paratus Sciences is proud to be an Equal Opportunity do not discriminate based upon race religion color national origin sex (including pregnancy childbirth or related medical conditions) sexual orientation gender gender identity gender expression transgender status sexual stereotypes age status as a protected veteran status as an individual with a disability or other applicable legally protected Sciences is committed to providing reasonable accommodations for candidates with disabilities in our recruiting process. If you need anyassistanceoraccommodationsdue to a disability please let us know at