Associate Scientist, Display Technologies
Job Location:
Job Location:
San Mateo, CA - USA
Monthly Salary:
$ 120000 - 135000
Monthly Salary:
Posted on:
9 days ago
Posted on:
Vacancies:
1 Vacancy
Vacancies:
Job Summary
The role: BigHat Biosciences is seeking a curious and motivated Associate Scientist to join the Display Technologies team. This individual will contribute to BigHats antibody discovery and engineering efforts and help generate high-quality data to improve BigHats machine learning models using display technologies working closely with senior scientists and cross-functional teams.
*At BigHat we believe in titles that commensurate with skill set relative organizational impact and value contribution; more experienced candidates are encouraged to apply with the understanding that responsibilities and title would adjust as appropriate.
Key Responsibilities
- Support R&D projects advancing display technologies at BigHat that expands BigHats antibody discovery capabilities and feed its ML models.
- Lead in the construction and QC of phage and yeast display libraries across diverse antibody formats (VHH scFv Fab) using standard molecular biology techniques (PCR molecular cloning electroporation).
- Execute phage and yeast display selections using naive and affinity and stability maturation libraries to discover and engineer antibodies with desired therapeutic properties.
- Express purify and characterize display-derived molecules using assays including ELISA flow cytometry BLI/SPR CE-SDS and others.
- Analyze selection results and contribute to discussions on next steps and future experimental design.
- Collaborate with BigHats Data Science and Machine Learning teams to inform library design and interpret selection data for model training.
- Present experimental plans and results during regular meetings with manager and science teams.
- Maintain thorough records using LIMS and electronic notebooks.
Skills Knowledge and Expertise
- BS or MS in Biochemistry Molecular Biology Bioengineering or a related field.
- 4 years of hands-on laboratory experience (academic or industry); relevant internship or research experience welcome.
- Familiarity with general molecular biology techniques (PCR molecular cloning gel electrophoresis).
- Exposure to antibody biology display technologies (phage or yeast) and protein expression.
- Demonstrated ability to follow protocols carefully troubleshoot experiments and maintain detailed lab records.
- Effective time management and clear written and verbal communication skills.
- Collaborative team-oriented mindset with an eagerness to learn in a fast-paced startup environment.
- Nice-to-haves include experience with flow cytometry ELISA or other binding assays and familiarity with NGS or automation platforms.
Total Rewards
The salary estimated for this position is $120000 - $135000 bonus options benefits. Compensation will vary depending on job-related knowledge skills and experience. Actual compensation will be confirmed in writing at the time of the offer.
What BigHat Offers:
What BigHat Offers:
- Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
- Dental and vision coverage through Guardian
- Additional well-being benefits through Nayya OneMedical Wagmo Rula and more
- 401(k) with company match
- DTO two weeks of company-wide shutdown and 12 company holidays
- Paid parental leave
Required Experience:
IC
About Company
BigHat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology. BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these desig ... View more
