Analytical Development Molecular Biologist

This position will be supporting an Analytical Development client team responsible for the characterization and testing of raw materials RNA drug substances and LNP drug products at different stages of development. The successful candidate will work closely with Quality Control Quality Assurance Process Development and R&D groups to advance preclinical gene editing candidates and support a growing gene editing pipeline.

We are seeking a skilled and motivated Analytical Development scientist to join a dynamic team focused on analytical assays for nucleic acid quantitation and next-generation sequencing (NGS). The position involves developing and executing analytical methods for non-GMP development studies including comparability assessments process development stability testing and product characterization. The candidate must be motivated detail-oriented and capable of supporting both routine testing activities and method development efforts.

Key Responsibilities:

• Perform molecular biology techniques such as qPCR d/ddPCR and work with DNA/RNA material to perform extraction purification reverse transcription amplification fragment size assessments electrophoresis methods and enzymatic manipulation reactions.
• Support and execute on activities to develop and qualify phase-appropriate analytical methods from the analytical research team intended for various activities including release and stability testing product characterization high-throughput analysis and characterization of complex raw materials.
• Potential execution of techniques including sterile tissue culture maintenance of mammalian cell culture preps and cell-based assays.
• Potential execution of NGS (next generation sequencing) workflows including library preparation.
• Collect process and analyze experimental data ensuring accurate and timely documentation in an electronic laboratory notebook (ELN).
• Review interpret and present data within the analytical team and cross-functionally.
• Maintain laboratory equipment and order critical reagents.
• Other duties as assigned.

Qualifications :

Minimum Required Qualifications:

• B.S./M.S. in Biological Sciences/Pharmaceutical Sciences Biochemistry Chemistry Analytical Chemistry or related field with at least 3 years of relevant laboratory industry experience.
• Proficiency with molecular biology techniques including DNA/RNA electrophoresis methods DNA amplification methods various DNA/RNA enzymatic manipulations cloning DNA/RNA research grade purification techniques DNA/RNA fragment size assessment techniques and dPCR/ddPCR.
• Some hands-on experience with NGS library preparation workflows for Illumina Pacbio and Oxford Nanopure sequencing platforms.
• Familiarity with sequence analysis software such as SnapGene or equivalent.
• Strong pipetting technique and meticulous attention to detail in laboratory settings.
• Strong aseptic technique with hands-on mammalian cell culture experience.
• Accurate and timely documentation practices with experience using an electronic laboratory notebook (ELN).

Preferred Qualifications:

• Experience working with various biophysical instrumentation such as DLS Osmometer pH and performing basic fluorescence-based assays.
• Hands-on experience with Illumina sequencers such as Miseq/Nextseq and Oxford Nanopore sequencer MinION.
• Basic knowledge of Linux environment and conceptual understanding of NGS data analysis pipeline in the Linux command line environment.
• Experience working with oligonucleotides or lipid nano particle (LNP) products and formulations.
• Experience working in a QC GMP environment with strong documentation and pipetting skills.
• Familiarity with gene editing techniques and related analytical methods.
• Direct experience with statistical analysis tools.
• Experience performing workflows using automation platforms.
• Strong understanding of analytical methodology and development.
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Additional Information :

The position is full-time Monday-Friday 8am-5pm with overtime as needed. Candidates living within a commutable distance of Boston MA are encouraged to apply.

Excellent full-time benefits include:

• Comprehensive medical coverage dental and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays
• Eligibility for yearly goal-based bonus & merit-based increases
• Compensation: $35.00-$41.00 per hour

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.

Remote Work :

No

Employment Type :

Full-time