Vedika Kuttanda

Vedika Kuttanda

Aspiring Data Scientist | Bioinformatics & Healthcare Analytics
United Arab Emirates
Kannada, Hindi

About Me

Bioinformatics & Aspiring Healthcare Data Science professional skilled in applying machine learning, statistics, and explainable AI to real-world problems in pharma, precision medicine, genomics, and clinical research. W…

Experience

Bioinformatician

Meta Biosciences · Mangalore, India
Mar 2025 - Present · 1 year 3 months

Built an automated Oxford Nanopore metagenomics pipeline: basecalling → adapter trimming (Porechop) → QC → host DNA removal → taxonomic classification using Kraken2 → summarized reports. Conducted sample QC, filtering, metadata merging, contamination detection, and downstream analysis for necrotic tissue samples.Collaborated with wet-lab teams to interpret microbial profiles for clinical relevance.Produced reproducible scripts, documentation, and standardized analysis reports.

ML + XAI for Anemia Diagnosis (Deployed Flask App)

Manipal University

Built ML models (RandomForest, AdaBoost, LightGBM) for clinical data classification (Vitamin B12 vs Folate Deficiency Anemia) using patient CBC data.
Applied statistical testing, EDA, feature selection.
Implemented feature engineering, model evaluation (accuracy, precision, recall, F1, MCC, AUC).
Performed hyperparameter tuning.
Designed experiments using cross-validation and GridSearchCV.
Used pandas, numpy, sklearn, matplotlib, and seaborn.
Achieved 99% accuracy.
Built REST API using Flask and deployed the best performing model locally.
Applied explainable AI (SHAP, LIME) for interpretability and transparency of the results.
Investigated RBC segmentation with U-Net (Python, OpenCV, TensorFlow).
Used data augmentation.
Used patch-wise training on 3D phase images for morphological analysis.

Transcriptomic Insights into MALAT1 in Cancer

Manipal University

Conducted RNA-seq analysis of TCGA datasets to study MALAT1 expression across multiple cancers.
Applied statistical modeling and pathway analysis to identify biomarker and therapeutic potential.

Designed a website using HTML and CSS

Manipal University

Designed a responsive website using HTML and CSS.
Supported calculation of users BMI to determine their ideal calorie intake.
Used BeautifulSoup for webscraping/API-extraction in a separate project.

Metagenomics Pipeline Automation

Metabiosciences (Internship), Associate with Manipal University

Built automated pipeline for Nanopore sequencing using Bash, Kraken2, Porechop, and Dorado.
Wrote reproducible workflows.
Generated QC dashboards.
Worked with Linux, HPC, and version-controlled workflows.

PROJECTS

Clinical ML + XAI for Folate vs B12 Anemia Diagnosis

Duration : 04-Jan-2025 - 30-Jun-2025

Worked as a project intern as a part of Masters thesis final dissertation to develop and deploy the machine learning model all the way from data collection and preprocessing till the deployment stage and model interpretability.Built ML models (RandomForest, AdaBoost, LightGBM) for clinical data classification (Vitamin B12 vs Folate Deficiency Anaemia) using patient CBC data. Applied statistical testing, EDA, and feature selection. Implemented feature engineering, model evaluation (accuracy, precision, recall, F1, MCC, AUC), hyperparameter tuning, experiment design (cross-validation, GridSearchCV), and used pandas, numpy, sklearn, matplotlib, and seaborn. The model performed very well with 99% accuracy.Built a REST API using Flask & deployed the best-performing model locally.Applied explainable AI (SHAP, LIME) for interpretability and transparency of the results. Tried to integrate RBC image-based morphological features for better classification.Deep learning: Investigated RBC segmentation with U-Net (Python, OpenCV, TensorFlow), data augmentation, and patch-wise training on 3D phase images for morphological analysis.Extracted shape descriptors, height–length curves, and statistical features for classification.Generated per-cell plots, CSV exports, and morphology profile visualizations.

Skills

Clinical Research Healthcare IT Python Data Science Good Communication Machine Learning Algorithms Workflow Management Bioinformatics Next Generation Sequencing QA/QC Qualitative Research R Programming Language (R) Research Experience Data Analysis and Reporting SQL Bash Git scikit-learn PyTorch TensorFlow XGBoost LightGBM SHAP LIME LangChain OpenAI API Prompt Engineering REST APIs Docker Flask AWS pandas numpy Snakemake Shell scripting nf-core Nextflow GitHub matplotlib seaborn Plotly OpenCV HTML CSS BeautifulSoup Kraken2 Porechop Dorado Linux HPC Cross-validation GridSearchCV Feature engineering Feature selection Statistical testing EDA Model evaluation Hyperparameter tuning Experiment design Data augmentation Patch-wise training RNA-seq analysis Pathway analysis
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