Matthew Hess

Matthew Hess

Bioinformatics Data Scientist
Canada

About Me

Lead bioinformatics scientist with 10+ years in clinical NGS diagnostics within CAP/CLIA/GMP-regulated environments, specializing in pipeline architecture, variant interpretation, and production-scale genomic workflows. …

Experience

Operations Manager

15581460 Canada Inc.

Directed cross-functional operations across 12 staff, increasing execution efficiency by 18% and stabilizing service delivery across core workflows, Deployed AI-enabled inventory system, reducing cost overruns by 25% and improving stock accuracy by 30% across supply operations, Restructured workforce model, eliminating redundancies and reducing labor expenditure by 30% while sustaining operational output, Standardized operational governance frameworks, reducing deviation rates by 22% and strengthening process control adherence across teams, Implemented performance monitoring systems, increasing productivity consistency by 15% through data-driven operational oversight

Bioinformatics Scientist

Biogen

Architected and scaled NGS pipelines for viral detection across cell bank and bulk harvest programs, supporting 20+ GMP-regulated manufacturing campaigns annually, Accelerated analysis throughput by 40% through optimized pipeline orchestration across AWS and on-premise compute environments, Established ALCOA-aligned data governance frameworks, sustaining 100% audit readiness across regulated bioinformatics workflows, Strengthened collaboration with virology, quality, and manufacturing teams, improving data integration and reducing issue resolution timelines by 30%

Bioinformatician

Progenity Inc.

Engineered variant interpretation workflows, reducing complex case review time by 35% and improving clinical decision turnaround, Sustained diagnostic accuracy above 98% across high-volume variant review operations within clinical genomics testing, Optimized sequencing workflows from extraction through data generation, increasing end-to-end efficiency by 28%, Resolved bioinformatics and operational constraints, achieving 99% adherence to clinical turnaround time targets across testing programs

Scientific Technologist

Progenity Inc.

Coordinated development operations across multiple programs, increasing on-time execution by 20% within product pipelines, Advanced development of 5+ laboratory-developed tests through structured experimental design and analytical validation workflows, Integrated automation frameworks into laboratory processes, reducing manual workload by 25% and improving reproducibility across assays

Skills

Java Python Confluence NGS Diagnostics Strategy Clinical Assay Development Variant Curation Frameworks Genomic Data Governance Bioinformatics Program Leadership Translational Genomics Clinical Workflow Optimization Quality Systems Implementation Pipeline Validation and Qualification Molecular Diagnostics Development Regulated Laboratory Operations Cross-Functional Scientific Integration PERL SQL Nextflow GATK Samtools IGV AWS S3 Git JIRA ClinVar dbSNP RVDB AWS
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